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Metallothionein expression and neurocognitive function in mice.

Publication ,  Journal Article
Levin, ED; Perraut, C; Pollard, N; Freedman, JH
Published in: Physiol Behav
March 30, 2006

Transition metals have been associated with impaired neurological development, and neurobehavioral activity. Metallothioneins are central components in the metabolism and detoxification of a variety of metals, however, little is known concerning their role in cognitive function. To determine the role of metallothionein in learning and memory, mice with deletions of two metallothionein genes (MT-1 and MT-2) were trained on a win-shift task in an 8-arm radial maze. The parental strain of mice learned the maze at a normal rate over an 18-session acquisition period. In contrast, the MT-1/MT-2-null mice, which had a similar choice accuracy level at the beginning of training, showed a poorer rate of learning during the training period. In addition, the MT-1/MT-2-null mice showed significantly less choice accuracy than the parental strain. The MT-1/MT-2-null mice also showed a significant hypoactivity during the early and middle parts of acquisition training, but they were not different from the wildtype controls during the final phase of training. Nicotine treatment, which can improve working memory, eliminated the impairment associated with the deletion of the MT-1 and MT-2 genes in a dose-related fashion after acquisition training in the aging adult mice. These results suggest that metallothioneins, through there roles in metal physiology or cellular protection, are involved in spatial learning and memory function.

Duke Scholars

Published In

Physiol Behav

DOI

ISSN

0031-9384

Publication Date

March 30, 2006

Volume

87

Issue

3

Start / End Page

513 / 518

Location

United States

Related Subject Headings

  • Nicotinic Agonists
  • Nicotine
  • Mice, Knockout
  • Mice
  • Metals
  • Metallothionein
  • Maze Learning
  • Male
  • Female
  • Dose-Response Relationship, Drug
 

Citation

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Chicago
ICMJE
MLA
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Levin, E. D., Perraut, C., Pollard, N., & Freedman, J. H. (2006). Metallothionein expression and neurocognitive function in mice. Physiol Behav, 87(3), 513–518. https://doi.org/10.1016/j.physbeh.2005.11.014
Levin, Edward D., Charles Perraut, Ninitia Pollard, and Jonathan H. Freedman. “Metallothionein expression and neurocognitive function in mice.Physiol Behav 87, no. 3 (March 30, 2006): 513–18. https://doi.org/10.1016/j.physbeh.2005.11.014.
Levin ED, Perraut C, Pollard N, Freedman JH. Metallothionein expression and neurocognitive function in mice. Physiol Behav. 2006 Mar 30;87(3):513–8.
Levin, Edward D., et al. “Metallothionein expression and neurocognitive function in mice.Physiol Behav, vol. 87, no. 3, Mar. 2006, pp. 513–18. Pubmed, doi:10.1016/j.physbeh.2005.11.014.
Levin ED, Perraut C, Pollard N, Freedman JH. Metallothionein expression and neurocognitive function in mice. Physiol Behav. 2006 Mar 30;87(3):513–518.
Journal cover image

Published In

Physiol Behav

DOI

ISSN

0031-9384

Publication Date

March 30, 2006

Volume

87

Issue

3

Start / End Page

513 / 518

Location

United States

Related Subject Headings

  • Nicotinic Agonists
  • Nicotine
  • Mice, Knockout
  • Mice
  • Metals
  • Metallothionein
  • Maze Learning
  • Male
  • Female
  • Dose-Response Relationship, Drug