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GW112, a novel antiapoptotic protein that promotes tumor growth.

Publication ,  Journal Article
Zhang, X; Huang, Q; Yang, Z; Li, Y; Li, C-Y
Published in: Cancer Res
April 1, 2004

GW112 is a novel gene that has little homology to other known genes. It is overexpressed in a number of human tumor types, especially in those of the digestive system. We show here that GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-beta-mediated cellular apoptosis and apoptosis-related gene expression. In addition, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. Taken together, our data suggest that GW112 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth.

Duke Scholars

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Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

April 1, 2004

Volume

64

Issue

7

Start / End Page

2474 / 2481

Location

United States

Related Subject Headings

  • Up-Regulation
  • Tretinoin
  • Oncology & Carcinogenesis
  • NADH, NADPH Oxidoreductases
  • Mitochondria
  • Interferon-beta
  • Hydrogen Peroxide
  • Humans
  • Hela Cells
  • HeLa Cells
 

Citation

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Zhang, X., Huang, Q., Yang, Z., Li, Y., & Li, C.-Y. (2004). GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res, 64(7), 2474–2481. https://doi.org/10.1158/0008-5472.can-03-3443
Zhang, Xiuwu, Qian Huang, Zhonghui Yang, Yongping Li, and Chuan-Yuan Li. “GW112, a novel antiapoptotic protein that promotes tumor growth.Cancer Res 64, no. 7 (April 1, 2004): 2474–81. https://doi.org/10.1158/0008-5472.can-03-3443.
Zhang X, Huang Q, Yang Z, Li Y, Li C-Y. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res. 2004 Apr 1;64(7):2474–81.
Zhang, Xiuwu, et al. “GW112, a novel antiapoptotic protein that promotes tumor growth.Cancer Res, vol. 64, no. 7, Apr. 2004, pp. 2474–81. Pubmed, doi:10.1158/0008-5472.can-03-3443.
Zhang X, Huang Q, Yang Z, Li Y, Li C-Y. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res. 2004 Apr 1;64(7):2474–2481.

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

April 1, 2004

Volume

64

Issue

7

Start / End Page

2474 / 2481

Location

United States

Related Subject Headings

  • Up-Regulation
  • Tretinoin
  • Oncology & Carcinogenesis
  • NADH, NADPH Oxidoreductases
  • Mitochondria
  • Interferon-beta
  • Hydrogen Peroxide
  • Humans
  • Hela Cells
  • HeLa Cells