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Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084.

Publication ,  Journal Article
Hitti, J; Andersen, J; McComsey, G; Liu, T; Melvin, A; Smith, L; Stek, A; Aberg, J; Hull, A; Alston-Smith, B; Watts, DH; Livingston, E ...
Published in: Am J Obstet Gynecol
April 2007

OBJECTIVE: The objective of the study was to determine whether protease inhibitors increase glucose intolerance and insulin resistance in pregnancy. STUDY DESIGN: In this multicenter, prospective, observational study, 149 human immunodeficiency virus-1-infected pregnant women had fasting insulin, glucose, and C-peptide measured followed by a 1 hour, 50 g glucose test. Glucose intolerance was defined as a 1 hour glucose greater than 130 mg/dL. Glucose intolerance, homeostasis model assessment of insulin resistance and pancreatic beta-cell function, and pregnancy outcomes were compared between those taking protease inhibitors and those not. RESULTS: Fifty-seven of 149 subjects (38%) had glucose intolerance. Body mass index, Hispanic ethnicity, and maternal age, but not protease inhibitors, were associated with glucose intolerance. There were no differences in insulin resistance, beta-cell function, or pregnancy outcome associated with protease inhibitor use. CONCLUSIONS: Protease inhibitors do not increase risk of glucose intolerance or insulin resistance among pregnant women.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

April 2007

Volume

196

Issue

4

Start / End Page

331.e1 / 331.e7

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Risk Assessment
  • Prospective Studies
  • Probability
  • Pregnancy Outcome
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Logistic Models
  • Infant, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hitti, J., Andersen, J., McComsey, G., Liu, T., Melvin, A., Smith, L., … AIDS Clinical Trials Group 5084 Study Team, . (2007). Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol, 196(4), 331.e1-331.e7. https://doi.org/10.1016/j.ajog.2006.11.037
Hitti, Jane, Janet Andersen, Grace McComsey, Tun Liu, Ann Melvin, Laura Smith, Alice Stek, et al. “Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084.Am J Obstet Gynecol 196, no. 4 (April 2007): 331.e1-331.e7. https://doi.org/10.1016/j.ajog.2006.11.037.
Hitti J, Andersen J, McComsey G, Liu T, Melvin A, Smith L, et al. Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol. 2007 Apr;196(4):331.e1-331.e7.
Hitti, Jane, et al. “Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084.Am J Obstet Gynecol, vol. 196, no. 4, Apr. 2007, pp. 331.e1-331.e7. Pubmed, doi:10.1016/j.ajog.2006.11.037.
Hitti J, Andersen J, McComsey G, Liu T, Melvin A, Smith L, Stek A, Aberg J, Hull A, Alston-Smith B, Watts DH, Livingston E, AIDS Clinical Trials Group 5084 Study Team. Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol. 2007 Apr;196(4):331.e1-331.e7.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

April 2007

Volume

196

Issue

4

Start / End Page

331.e1 / 331.e7

Location

United States

Related Subject Headings

  • Statistics, Nonparametric
  • Risk Assessment
  • Prospective Studies
  • Probability
  • Pregnancy Outcome
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Logistic Models
  • Infant, Newborn