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Assessing medication effects in the MTA study using neuropsychological outcomes.

Publication ,  Journal Article
Epstein, JN; Conners, CK; Hervey, AS; Tonev, ST; Arnold, LE; Abikoff, HB; Elliott, G; Greenhill, LL; Hechtman, L; Hoagwood, K; Hinshaw, SP ...
Published in: J Child Psychol Psychiatry
May 2006

BACKGROUND: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. METHODS: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). RESULTS: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. CONCLUSIONS: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.

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Published In

J Child Psychol Psychiatry

DOI

ISSN

0021-9630

Publication Date

May 2006

Volume

47

Issue

5

Start / End Page

446 / 456

Location

England

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Task Performance and Analysis
  • Reaction Time
  • Pemoline
  • Normal Distribution
  • Neuropsychological Tests
  • Methylphenidate
  • Humans
  • Follow-Up Studies
 

Citation

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Epstein, J. N., Conners, C. K., Hervey, A. S., Tonev, S. T., Arnold, L. E., Abikoff, H. B., … MTA Cooperative Study Group. (2006). Assessing medication effects in the MTA study using neuropsychological outcomes. J Child Psychol Psychiatry, 47(5), 446–456. https://doi.org/10.1111/j.1469-7610.2005.01469.x
Epstein, Jeffery N., C Keith Conners, Aaron S. Hervey, Simon T. Tonev, L Eugene Arnold, Howard B. Abikoff, Glen Elliott, et al. “Assessing medication effects in the MTA study using neuropsychological outcomes.J Child Psychol Psychiatry 47, no. 5 (May 2006): 446–56. https://doi.org/10.1111/j.1469-7610.2005.01469.x.
Epstein JN, Conners CK, Hervey AS, Tonev ST, Arnold LE, Abikoff HB, et al. Assessing medication effects in the MTA study using neuropsychological outcomes. J Child Psychol Psychiatry. 2006 May;47(5):446–56.
Epstein, Jeffery N., et al. “Assessing medication effects in the MTA study using neuropsychological outcomes.J Child Psychol Psychiatry, vol. 47, no. 5, May 2006, pp. 446–56. Pubmed, doi:10.1111/j.1469-7610.2005.01469.x.
Epstein JN, Conners CK, Hervey AS, Tonev ST, Arnold LE, Abikoff HB, Elliott G, Greenhill LL, Hechtman L, Hoagwood K, Hinshaw SP, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Wells K, Vitiello B, Wigal T, MTA Cooperative Study Group. Assessing medication effects in the MTA study using neuropsychological outcomes. J Child Psychol Psychiatry. 2006 May;47(5):446–456.
Journal cover image

Published In

J Child Psychol Psychiatry

DOI

ISSN

0021-9630

Publication Date

May 2006

Volume

47

Issue

5

Start / End Page

446 / 456

Location

England

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Task Performance and Analysis
  • Reaction Time
  • Pemoline
  • Normal Distribution
  • Neuropsychological Tests
  • Methylphenidate
  • Humans
  • Follow-Up Studies