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Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture.

Publication ,  Journal Article
Futreal, PA; Cochran, C; Rosenthal, J; Miki, Y; Swenson, J; Hobbs, M; Bennett, LM; Haugen-Strano, A; Marks, J; Barrett, JC
Published in: Hum Mol Genet
August 1994

Using the technique of solution hybridization coupled with magnetic bead capture, we have isolated a novel homeobox-containing gene from the BRCA1 region of 17q21. This gene is the human homologue of the mouse Mox1 gene previously localized to a syntenic region of mouse chromosome 11. Multiple overlapping cDNAs of human MOX1 were identified using both a cosmid and a P1 genomic clone containing the microsatellite markers D17S750 and D17S858 which map within the BRCA1 region defined by D17S776 and D17S78. MOX1 expression was observed in a variety of normal tissues examined, including breast and ovary. Given that the gene contains a homeobox domain and has the potential to regulate growth and differentiation, MOX1 represents an attractive candidate for the BRCA1 gene. This possibility was investigated in a series of BRCA1 kindreds and primary sporadic breast tumors. No evidence for mutation was found in the coding sequence, making it unlikely that MOX1 is the BRCA1 gene. However, the widespread expression of MOX1 in non-embryonal tissues suggests a role in normal cell biology which warrants further study.

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Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

August 1994

Volume

3

Issue

8

Start / End Page

1359 / 1364

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Polymerase Chain Reaction
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Humans
  • Genetics & Heredity
  • Genes, Homeobox
  • DNA Mutational Analysis
  • Chromosomes, Human, Pair 17
  • Chromosome Mapping
 

Citation

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Futreal, P. A., Cochran, C., Rosenthal, J., Miki, Y., Swenson, J., Hobbs, M., … Barrett, J. C. (1994). Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Hum Mol Genet, 3(8), 1359–1364. https://doi.org/10.1093/hmg/3.8.1359
Futreal, P. A., C. Cochran, J. Rosenthal, Y. Miki, J. Swenson, M. Hobbs, L. M. Bennett, A. Haugen-Strano, J. Marks, and J. C. Barrett. “Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture.Hum Mol Genet 3, no. 8 (August 1994): 1359–64. https://doi.org/10.1093/hmg/3.8.1359.
Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, et al. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Hum Mol Genet. 1994 Aug;3(8):1359–64.
Futreal, P. A., et al. “Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture.Hum Mol Genet, vol. 3, no. 8, Aug. 1994, pp. 1359–64. Pubmed, doi:10.1093/hmg/3.8.1359.
Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M, Bennett LM, Haugen-Strano A, Marks J, Barrett JC. Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. Hum Mol Genet. 1994 Aug;3(8):1359–1364.
Journal cover image

Published In

Hum Mol Genet

DOI

ISSN

0964-6906

Publication Date

August 1994

Volume

3

Issue

8

Start / End Page

1359 / 1364

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Polymerase Chain Reaction
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Humans
  • Genetics & Heredity
  • Genes, Homeobox
  • DNA Mutational Analysis
  • Chromosomes, Human, Pair 17
  • Chromosome Mapping