A genomic regulatory network for development.
Publication
, Journal Article
Davidson, EH; Rast, JP; Oliveri, P; Ransick, A; Calestani, C; Yuh, C-H; Minokawa, T; Amore, G; Hinman, V; Arenas-Mena, C; Otim, O; Brown, CT ...
Published in: Science (New York, N.Y.)
March 2002
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
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Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
March 2002
Volume
295
Issue
5560
Start / End Page
1669 / 1678
Related Subject Headings
- Systems Theory
- Stem Cells
- Sea Urchins
- Regulatory Sequences, Nucleic Acid
- Morphogenesis
- Models, Genetic
- Models, Biological
- Mesoderm
- Genome
- Genes, Regulator
Citation
APA
Chicago
ICMJE
MLA
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Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C.-H., … Bolouri, H. (2002). A genomic regulatory network for development. Science (New York, N.Y.), 295(5560), 1669–1678. https://doi.org/10.1126/science.1069883
Davidson, Eric H., Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou-Hwa Yuh, Takuya Minokawa, et al. “A genomic regulatory network for development.” Science (New York, N.Y.) 295, no. 5560 (March 2002): 1669–78. https://doi.org/10.1126/science.1069883.
Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh C-H, et al. A genomic regulatory network for development. Science (New York, NY). 2002 Mar;295(5560):1669–78.
Davidson, Eric H., et al. “A genomic regulatory network for development.” Science (New York, N.Y.), vol. 295, no. 5560, Mar. 2002, pp. 1669–78. Epmc, doi:10.1126/science.1069883.
Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh C-H, Minokawa T, Amore G, Hinman V, Arenas-Mena C, Otim O, Brown CT, Livi CB, Lee PY, Revilla R, Rust AG, Pan ZJ, Schilstra MJ, Clarke PJC, Arnone MI, Rowen L, Cameron RA, McClay DR, Hood L, Bolouri H. A genomic regulatory network for development. Science (New York, NY). 2002 Mar;295(5560):1669–1678.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
March 2002
Volume
295
Issue
5560
Start / End Page
1669 / 1678
Related Subject Headings
- Systems Theory
- Stem Cells
- Sea Urchins
- Regulatory Sequences, Nucleic Acid
- Morphogenesis
- Models, Genetic
- Models, Biological
- Mesoderm
- Genome
- Genes, Regulator