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Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons.

Publication ,  Journal Article
Lieth, E; McClay, DR; Lauder, JM
Published in: Glia
January 1990

To study the interactions between neurons of known transmitter phenotype and non-neuronal cells of glial or fibroblastic origin, serotonergic (5-HT) neurons were tested for their strength of adhesion and neurite outgrowth patterns on substrates of astrocytes or fibroblasts using a cell adhesion assay for transmitter-identified neurons, and morphometry of immunocytochemically stained neurons in dissociated cell cultures. Both the strength of adhesion and the rate and complexity of neurite outgrowth by 5-HT neurons were significantly greater on substrates of astrocytes compared to fibroblasts. These results provide evidence that 5-HT neurons can interact selectively with glia via cell surface determinants, and that this process may be important for the development of complex (dendrite-like) neuritic arbors. The methods developed in this study will be useful for future studies of interactions between transmitter-identified neurons and glial cells during ontogeny of the embryonic brain.

Duke Scholars

Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

January 1990

Volume

3

Issue

3

Start / End Page

169 / 179

Related Subject Headings

  • Serotonin
  • Rats
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Fibroblasts
  • Dendrites
  • Cerebral Cortex
  • Cells, Cultured
  • Cell Differentiation
 

Citation

APA
Chicago
ICMJE
MLA
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Lieth, E., McClay, D. R., & Lauder, J. M. (1990). Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons. Glia, 3(3), 169–179. https://doi.org/10.1002/glia.440030304
Lieth, E., D. R. McClay, and J. M. Lauder. “Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons.Glia 3, no. 3 (January 1990): 169–79. https://doi.org/10.1002/glia.440030304.
Lieth, E., et al. “Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons.Glia, vol. 3, no. 3, Jan. 1990, pp. 169–79. Epmc, doi:10.1002/glia.440030304.

Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

January 1990

Volume

3

Issue

3

Start / End Page

169 / 179

Related Subject Headings

  • Serotonin
  • Rats
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Fibroblasts
  • Dendrites
  • Cerebral Cortex
  • Cells, Cultured
  • Cell Differentiation