The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer
Publication
, Journal Article
McDonnell, DP; Yee, D; Santen, R; Osborne, K; Brodie, A
Published in: Clinical Cancer Research
January 15, 2005
In addition to physiologic activities in the reproductive, skeletal, and central nervous systems, estrogens have been shown to play important roles in the aberrant cell proliferation observed in breast and reproductive tract cancers. Not surprisingly, pharmaceuticals that target different steps in the estrogen signal transduction pathway have found widespread use in the treatment of a wide variety of estrogen-linked disorders. The goal of this review is to outline what is known about the molecular pharmacology of the estrogen receptor and discuss how this information can be used to guide selection of drugs for a particular therapeutic application, and identify new targets where pharmaceutical exploitation could yield novel therapeutics.
Duke Scholars
Published In
Clinical Cancer Research
ISSN
1078-0432
Publication Date
January 15, 2005
Volume
11
Issue
2 II
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
McDonnell, D. P., Yee, D., Santen, R., Osborne, K., & Brodie, A. (2005). The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer. Clinical Cancer Research, 11(2 II).
McDonnell, D. P., D. Yee, R. Santen, K. Osborne, and A. Brodie. “The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer.” Clinical Cancer Research 11, no. 2 II (January 15, 2005).
McDonnell DP, Yee D, Santen R, Osborne K, Brodie A. The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer. Clinical Cancer Research. 2005 Jan 15;11(2 II).
McDonnell, D. P., et al. “The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer.” Clinical Cancer Research, vol. 11, no. 2 II, Jan. 2005.
McDonnell DP, Yee D, Santen R, Osborne K, Brodie A. The molecular pharmacology of estrogen receptor modulators: Implications for the treatment of breast cancer. Clinical Cancer Research. 2005 Jan 15;11(2 II).
Published In
Clinical Cancer Research
ISSN
1078-0432
Publication Date
January 15, 2005
Volume
11
Issue
2 II
Related Subject Headings
- Oncology & Carcinogenesis
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis