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The mechanism of action of steroid hormones: a new twist to an old tale.

Publication ,  Journal Article
McDonnell, DP; Clevenger, B; Dana, S; Santiso-Mere, D; Tzukerman, MT; Gleeson, MA
Published in: J Clin Pharmacol
December 1993

Steroid hormones, vitamins, and thyroid hormone are potent chemical messengers that exert dramatic effects on cell differentiation, homeostasis, and morphogenesis. These molecules, though diverse in structure, share a mechanistically similar mode of action. The effector molecules diffuse across cellular membranes and bind to specific high affinity receptors in the target cell nuclei. This interaction results in the conversion of an inactive receptor to one that can interact with the regulatory regions of target genes and modulate the rate of transcription of specific gene sets. The recent cloning and characterization of the functional receptors for these hormones has been enlightening as to the individual steps involved in steroid signal transduction. In addition, emerging evidence suggests that receptor function can be influenced by cell and promoter context indicating that it may be possible to develop tissue specific or tissue-restricted drugs. The concept that a single receptor can modulate gene transcription in a cell-specific manner is of great medical and pharmaceutical importance. The focus of this review is to highlight the recent developments in the steroid receptor field and to illustrate the novel approaches been undertaken to identify novel pharmaceuticals.

Duke Scholars

Published In

J Clin Pharmacol

DOI

ISSN

0091-2700

Publication Date

December 1993

Volume

33

Issue

12

Start / End Page

1165 / 1172

Location

England

Related Subject Headings

  • Steroids
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • Pharmacology & Pharmacy
  • Humans
  • Animals
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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McDonnell, D. P., Clevenger, B., Dana, S., Santiso-Mere, D., Tzukerman, M. T., & Gleeson, M. A. (1993). The mechanism of action of steroid hormones: a new twist to an old tale. J Clin Pharmacol, 33(12), 1165–1172. https://doi.org/10.1002/j.1552-4604.1993.tb03916.x
McDonnell, D. P., B. Clevenger, S. Dana, D. Santiso-Mere, M. T. Tzukerman, and M. A. Gleeson. “The mechanism of action of steroid hormones: a new twist to an old tale.J Clin Pharmacol 33, no. 12 (December 1993): 1165–72. https://doi.org/10.1002/j.1552-4604.1993.tb03916.x.
McDonnell DP, Clevenger B, Dana S, Santiso-Mere D, Tzukerman MT, Gleeson MA. The mechanism of action of steroid hormones: a new twist to an old tale. J Clin Pharmacol. 1993 Dec;33(12):1165–72.
McDonnell, D. P., et al. “The mechanism of action of steroid hormones: a new twist to an old tale.J Clin Pharmacol, vol. 33, no. 12, Dec. 1993, pp. 1165–72. Pubmed, doi:10.1002/j.1552-4604.1993.tb03916.x.
McDonnell DP, Clevenger B, Dana S, Santiso-Mere D, Tzukerman MT, Gleeson MA. The mechanism of action of steroid hormones: a new twist to an old tale. J Clin Pharmacol. 1993 Dec;33(12):1165–1172.
Journal cover image

Published In

J Clin Pharmacol

DOI

ISSN

0091-2700

Publication Date

December 1993

Volume

33

Issue

12

Start / End Page

1165 / 1172

Location

England

Related Subject Headings

  • Steroids
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • Pharmacology & Pharmacy
  • Humans
  • Animals
  • 1115 Pharmacology and Pharmaceutical Sciences