Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors
Publication
, Journal Article
Fuqua, SAW; Fitzgerald, SD; Allred, DC; Elledge, RM; Nawaz, Z; McDonnell, DP; O'Malley, BW; Greene, GL; McGuire, WL
Published in: Cancer Research
1992
It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But patients with discordant receptors, the ER+/PgR- phenotype, are often intermediate in clinical response. We focused upon this group of patients and have identified a truncated ER which is abundant in some ER+/PgR- breast tumors and which inhibits the binding of wild-type ER to its cognate response element. This variant interferes in a dominant negative manner with wild-type ER function and may represent a mechanism for modulation of estrogen responsiveness.
Duke Scholars
Published In
Cancer Research
ISSN
0008-5472
Publication Date
1992
Volume
52
Issue
2
Start / End Page
483 / 486
Related Subject Headings
- Oncology & Carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Fuqua, S. A. W., Fitzgerald, S. D., Allred, D. C., Elledge, R. M., Nawaz, Z., McDonnell, D. P., … McGuire, W. L. (1992). Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Research, 52(2), 483–486.
Fuqua, S. A. W., S. D. Fitzgerald, D. C. Allred, R. M. Elledge, Z. Nawaz, D. P. McDonnell, B. W. O’Malley, G. L. Greene, and W. L. McGuire. “Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.” Cancer Research 52, no. 2 (1992): 483–86.
Fuqua SAW, Fitzgerald SD, Allred DC, Elledge RM, Nawaz Z, McDonnell DP, et al. Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Research. 1992;52(2):483–6.
Fuqua, S. A. W., et al. “Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.” Cancer Research, vol. 52, no. 2, 1992, pp. 483–86.
Fuqua SAW, Fitzgerald SD, Allred DC, Elledge RM, Nawaz Z, McDonnell DP, O’Malley BW, Greene GL, McGuire WL. Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Research. 1992;52(2):483–486.
Published In
Cancer Research
ISSN
0008-5472
Publication Date
1992
Volume
52
Issue
2
Start / End Page
483 / 486
Related Subject Headings
- Oncology & Carcinogenesis
- 1112 Oncology and Carcinogenesis