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Intravenous phenytoin is an effective anticonvulsant in the kindling model.

Publication ,  Journal Article
McNamara, JO; Rigsbee, LC; Butler, LS; Shin, C
Published in: Ann Neurol
November 1989

We reexamined the efficacy of the clinically effective anticonvulsant drug phenytoin in the kindling model. We investigated the effects of varying doses of intravenous phenytoin on serum concentrations and on several indexes of stimulation-evoked kindled seizures. Intravenous phenytoin produced a dose-dependent increase in serum phenytoin concentration and powerfully suppressed both limbic and clonic motor seizures. Although focal afterdischarge threshold was elevated to some extent, the most profound effect of phenytoin was limitation of seizure propagation. Variable and low serum concentrations of intraperitoneal or oral phenytoin may explain previous findings that phenytoin is only partly effective or ineffective against kindled seizures. Together with previous results with other drugs, the excellent correlation among drugs effective against human and kindled seizures strengthens the validity of this model. We suggest that the efficacy of experimental anticonvulsant drugs be established in the kindling model before initiation of clinical trials for partial and secondarily generalized seizures.

Duke Scholars

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1989

Volume

26

Issue

5

Start / End Page

675 / 678

Location

United States

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Phenytoin
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Injections, Intravenous
  • Dose-Response Relationship, Drug
  • Anticonvulsants
 

Citation

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ICMJE
MLA
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McNamara, J. O., Rigsbee, L. C., Butler, L. S., & Shin, C. (1989). Intravenous phenytoin is an effective anticonvulsant in the kindling model. Ann Neurol, 26(5), 675–678. https://doi.org/10.1002/ana.410260514
McNamara, J. O., L. C. Rigsbee, L. S. Butler, and C. Shin. “Intravenous phenytoin is an effective anticonvulsant in the kindling model.Ann Neurol 26, no. 5 (November 1989): 675–78. https://doi.org/10.1002/ana.410260514.
McNamara JO, Rigsbee LC, Butler LS, Shin C. Intravenous phenytoin is an effective anticonvulsant in the kindling model. Ann Neurol. 1989 Nov;26(5):675–8.
McNamara, J. O., et al. “Intravenous phenytoin is an effective anticonvulsant in the kindling model.Ann Neurol, vol. 26, no. 5, Nov. 1989, pp. 675–78. Pubmed, doi:10.1002/ana.410260514.
McNamara JO, Rigsbee LC, Butler LS, Shin C. Intravenous phenytoin is an effective anticonvulsant in the kindling model. Ann Neurol. 1989 Nov;26(5):675–678.
Journal cover image

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1989

Volume

26

Issue

5

Start / End Page

675 / 678

Location

United States

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Phenytoin
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • Injections, Intravenous
  • Dose-Response Relationship, Drug
  • Anticonvulsants