Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.
Publication
, Journal Article
Bonhaus, DW; McNamara, JO
Published in: Brain Res
January 12, 1988
Intranigral gamma-vinyl-GABA (GVG) suppresses electroshock seizures (ES). This anticonvulsant action was blocked by systemic treatment with the alpha 2-antagonist idazoxan. Consequently, we tested the idea that intranigral GABA mimetics suppress ES by increasing noradrenergic (NE) neuronal activity. Contrary to our hypothesis, GVG decreased NE turnover. This result indicates that while the seizure-suppressant effect of intranigral GVG requires alpha 2-mediated NE neurotransmission, the mechanism of this anticonvulsant action is not by increasing NE neuronal activity.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
January 12, 1988
Volume
438
Issue
1-2
Start / End Page
391 / 394
Location
Netherlands
Related Subject Headings
- Vigabatrin
- Substantia Nigra
- Spinal Cord
- Seizures
- Receptors, Adrenergic, alpha
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Muscimol
- Idazoxan
Citation
APA
Chicago
ICMJE
MLA
NLM
Bonhaus, D. W., & McNamara, J. O. (1988). Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. Brain Res, 438(1–2), 391–394. https://doi.org/10.1016/0006-8993(88)91370-4
Bonhaus, D. W., and J. O. McNamara. “Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.” Brain Res 438, no. 1–2 (January 12, 1988): 391–94. https://doi.org/10.1016/0006-8993(88)91370-4.
Bonhaus DW, McNamara JO. Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. Brain Res. 1988 Jan 12;438(1–2):391–4.
Bonhaus, D. W., and J. O. McNamara. “Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.” Brain Res, vol. 438, no. 1–2, Jan. 1988, pp. 391–94. Pubmed, doi:10.1016/0006-8993(88)91370-4.
Bonhaus DW, McNamara JO. Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. Brain Res. 1988 Jan 12;438(1–2):391–394.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
January 12, 1988
Volume
438
Issue
1-2
Start / End Page
391 / 394
Location
Netherlands
Related Subject Headings
- Vigabatrin
- Substantia Nigra
- Spinal Cord
- Seizures
- Receptors, Adrenergic, alpha
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Muscimol
- Idazoxan