Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
Publication
, Journal Article
Shin, C; Rigsbee, LC; McNamara, JO
Published in: Brain Res
November 29, 1986
We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also suppressed both generalized motor seizures and electrographic after discharges in previously fully kindled animals. These results further support the idea that enhanced GABAergic neurotransmission suppresses both seizures and epileptogenesis. The results also suggest that GVG may be an effective anti-seizure and anti-epileptogenic agent in humans.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 29, 1986
Volume
398
Issue
2
Start / End Page
370 / 374
Location
Netherlands
Related Subject Headings
- gamma-Aminobutyric Acid
- Vigabatrin
- Synaptic Transmission
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Male
- Kindling, Neurologic
- Epilepsy, Temporal Lobe
- Electrophysiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Shin, C., Rigsbee, L. C., & McNamara, J. O. (1986). Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res, 398(2), 370–374. https://doi.org/10.1016/0006-8993(86)91498-8
Shin, C., L. C. Rigsbee, and J. O. McNamara. “Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.” Brain Res 398, no. 2 (November 29, 1986): 370–74. https://doi.org/10.1016/0006-8993(86)91498-8.
Shin C, Rigsbee LC, McNamara JO. Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res. 1986 Nov 29;398(2):370–4.
Shin, C., et al. “Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.” Brain Res, vol. 398, no. 2, Nov. 1986, pp. 370–74. Pubmed, doi:10.1016/0006-8993(86)91498-8.
Shin C, Rigsbee LC, McNamara JO. Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res. 1986 Nov 29;398(2):370–374.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 29, 1986
Volume
398
Issue
2
Start / End Page
370 / 374
Location
Netherlands
Related Subject Headings
- gamma-Aminobutyric Acid
- Vigabatrin
- Synaptic Transmission
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Male
- Kindling, Neurologic
- Epilepsy, Temporal Lobe
- Electrophysiology