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Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors.

Publication ,  Journal Article
Montebugnoli, L; Servidio, D; Miaton, RA; Prati, C; Tricoci, P; Melloni, C
Published in: J Clin Periodontol
January 2004

OBJECTIVES: To assess the relationship between poor oral health and coronary heart disease (CHD) and systemic inflammatory and haemostatic factors in an Italian population. MATERIAL AND METHODS: The study population consisted of 63 males aged 40-65 years with proven CHD and 50 controls matched for age, geographic area, and socioeconomic status. A detailed description of their oral status was given using four different dental indices (total dental index (TDI), panoramic tomography score, clinical periodontal sum score (CPSS), and clinical and radiographic sum score (CRSS)). Blood samples were taken for measurement of the following CHD risk factors: serum total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and glucose; a series of systemic markers of inflammation (C-reactive protein, leucocytes, fibrinogen, homocysteine) and a series of haemostatic factors (von Willebrand factor, fibrin D-dimer, prothrombinic fragment F1.2, plasminogen activator inhibitor type I (PAI-1), and serum antibodies) against oxidized LDL (anti-Ox-LDL). RESULTS: Multiple logistic regression adjusted for all risk factors for CHD showed statistically significant relationships (p<0.01) between all dental indices and CHD. Significant relationships (p always <0.01) were found between CPSS and CRSS and leucocyte count. Significant relationships (p always <0.05) were also found between TDI and the von Willebrand factor, and between CPSS and the von Willebrand factor, anti-Ox-LDL, and PAI-1. CONCLUSIONS: The present study suggests an association between poor oral status and CHD, and provides evidence that inflammatory and haemostatic factors could play an important role in this association.

Duke Scholars

Published In

J Clin Periodontol

DOI

ISSN

0303-6979

Publication Date

January 2004

Volume

31

Issue

1

Start / End Page

25 / 29

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Triglycerides
  • Tooth Diseases
  • Statistics, Nonparametric
  • Radiography, Panoramic
  • Prothrombin
  • Periodontal Index
  • Periodontal Diseases
  • Peptide Fragments
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Montebugnoli, L., Servidio, D., Miaton, R. A., Prati, C., Tricoci, P., & Melloni, C. (2004). Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. J Clin Periodontol, 31(1), 25–29. https://doi.org/10.1111/j.0303-6979.2004.00432.x
Montebugnoli, L., D. Servidio, R. A. Miaton, C. Prati, P. Tricoci, and C. Melloni. “Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors.J Clin Periodontol 31, no. 1 (January 2004): 25–29. https://doi.org/10.1111/j.0303-6979.2004.00432.x.
Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C. Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. J Clin Periodontol. 2004 Jan;31(1):25–9.
Montebugnoli, L., et al. “Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors.J Clin Periodontol, vol. 31, no. 1, Jan. 2004, pp. 25–29. Pubmed, doi:10.1111/j.0303-6979.2004.00432.x.
Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C. Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. J Clin Periodontol. 2004 Jan;31(1):25–29.
Journal cover image

Published In

J Clin Periodontol

DOI

ISSN

0303-6979

Publication Date

January 2004

Volume

31

Issue

1

Start / End Page

25 / 29

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Triglycerides
  • Tooth Diseases
  • Statistics, Nonparametric
  • Radiography, Panoramic
  • Prothrombin
  • Periodontal Index
  • Periodontal Diseases
  • Peptide Fragments
  • Middle Aged