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Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.

Publication ,  Journal Article
Gaufin, T; Gautam, R; Kasheta, M; Ribeiro, R; Ribka, E; Barnes, M; Pattison, M; Tatum, C; MacFarland, J; Montefiori, D; Kaur, A; Pandrea, I ...
Published in: Blood
April 30, 2009

We investigated the impact of rhesus macaque (RM) B-cell depletion before inoculation with the isolate SIVsmmD215. Seven RMs were treated every 3 weeks with 50 mg/kg of an anti-CD20 antibody (rituximab) starting 7 days before inoculation for 2 (n = 4) and 5 (n = 3) months. Four control animals received no antibody. Three animals were completely depleted of CD20(+) B cells, but 4 were only partially depleted of CD20 cells in the LNs and intestine. The decrease in antibody production was consistent with the efficacy of tissue CD20 depletion. Seroconversion and neutralizing antibody production was significantly delayed in animals showing complete tissue CD20 depletion and remained at low titers in all CD20-depleted RMs. Surprisingly, there was no significant difference in acute or chronic viral loads between CD20-depleted and control animal groups. There was a tendency for lower viral set points in CD20-depleted animals. At 6 weeks after inoculation, cellular immune responses were significantly stronger in CD20-depleted animals than in controls. There was no significant difference in survival between CD20-depleted and control animals. Our data suggest that a deficiency of Ab responses did not markedly affect viral replication or disease progression and that they may be compensated by more robust cellular responses.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

April 30, 2009

Volume

113

Issue

18

Start / End Page

4250 / 4261

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Viral Load
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rituximab
  • Male
  • Macaca mulatta
 

Citation

APA
Chicago
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MLA
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Gaufin, T., Gautam, R., Kasheta, M., Ribeiro, R., Ribka, E., Barnes, M., … Apetrei, C. (2009). Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. Blood, 113(18), 4250–4261. https://doi.org/10.1182/blood-2008-09-177741
Gaufin, Thaidra, Rajeev Gautam, Melissa Kasheta, Ruy Ribeiro, Erin Ribka, Mary Barnes, Melissa Pattison, et al. “Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.Blood 113, no. 18 (April 30, 2009): 4250–61. https://doi.org/10.1182/blood-2008-09-177741.
Gaufin T, Gautam R, Kasheta M, Ribeiro R, Ribka E, Barnes M, et al. Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. Blood. 2009 Apr 30;113(18):4250–61.
Gaufin, Thaidra, et al. “Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.Blood, vol. 113, no. 18, Apr. 2009, pp. 4250–61. Pubmed, doi:10.1182/blood-2008-09-177741.
Gaufin T, Gautam R, Kasheta M, Ribeiro R, Ribka E, Barnes M, Pattison M, Tatum C, MacFarland J, Montefiori D, Kaur A, Pandrea I, Apetrei C. Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. Blood. 2009 Apr 30;113(18):4250–4261.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

April 30, 2009

Volume

113

Issue

18

Start / End Page

4250 / 4261

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Viral Load
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Rituximab
  • Male
  • Macaca mulatta