Discovery of thiophene inhibitors of polo-like kinase.
Publication
, Journal Article
Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW ...
Published in: Bioorg Med Chem Lett
February 1, 2009
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
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Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
February 1, 2009
Volume
19
Issue
3
Start / End Page
1018 / 1021
Location
England
Related Subject Headings
- Thiophenes
- Proto-Oncogene Proteins
- Protein Serine-Threonine Kinases
- Polo-Like Kinase 1
- Molecular Conformation
- Models, Chemical
- Mitosis
- Mice
- Medicinal & Biomolecular Chemistry
- Inhibitory Concentration 50
Citation
APA
Chicago
ICMJE
MLA
NLM
Emmitte, K. A., Andrews, C. W., Badiang, J. G., Davis-Ward, R. G., Dickson, H. D., Drewry, D. H., … Cheung, M. (2009). Discovery of thiophene inhibitors of polo-like kinase. Bioorg Med Chem Lett, 19(3), 1018–1021. https://doi.org/10.1016/j.bmcl.2008.11.041
Emmitte, Kyle A., C Webb Andrews, Jennifer G. Badiang, Ronda G. Davis-Ward, Hamilton D. Dickson, David H. Drewry, Holly K. Emerson, et al. “Discovery of thiophene inhibitors of polo-like kinase.” Bioorg Med Chem Lett 19, no. 3 (February 1, 2009): 1018–21. https://doi.org/10.1016/j.bmcl.2008.11.041.
Emmitte KA, Andrews CW, Badiang JG, Davis-Ward RG, Dickson HD, Drewry DH, et al. Discovery of thiophene inhibitors of polo-like kinase. Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018–21.
Emmitte, Kyle A., et al. “Discovery of thiophene inhibitors of polo-like kinase.” Bioorg Med Chem Lett, vol. 19, no. 3, Feb. 2009, pp. 1018–21. Pubmed, doi:10.1016/j.bmcl.2008.11.041.
Emmitte KA, Andrews CW, Badiang JG, Davis-Ward RG, Dickson HD, Drewry DH, Emerson HK, Epperly AH, Hassler DF, Knick VB, Kuntz KW, Lansing TJ, Linn JA, Mook RA, Nailor KE, Salovich JM, Spehar GM, Cheung M. Discovery of thiophene inhibitors of polo-like kinase. Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018–1021.
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
February 1, 2009
Volume
19
Issue
3
Start / End Page
1018 / 1021
Location
England
Related Subject Headings
- Thiophenes
- Proto-Oncogene Proteins
- Protein Serine-Threonine Kinases
- Polo-Like Kinase 1
- Molecular Conformation
- Models, Chemical
- Mitosis
- Mice
- Medicinal & Biomolecular Chemistry
- Inhibitory Concentration 50