Skip to main content
Journal cover image

Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.

Publication ,  Journal Article
Henke, BR; Adkison, KK; Blanchard, SG; Leesnitzer, LM; Mook, RA; Plunket, KD; Ray, JA; Roberson, C; Unwalla, R; Willson, TM
Published in: Bioorg Med Chem Lett
December 6, 1999

The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. These new analogs are selective for PPARgamma vs the other PPAR subtypes, and the most potent compounds in this series are comparable to in vitro potencies at PPARgamma reported for the thiazolidinedione-based antidiabetic drugs currently in clinical use.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Bioorg Med Chem Lett

DOI

ISSN

0960-894X

Publication Date

December 6, 1999

Volume

9

Issue

23

Start / End Page

3329 / 3334

Location

England

Related Subject Headings

  • Transcription Factors
  • Structure-Activity Relationship
  • Receptors, Cytoplasmic and Nuclear
  • Rats
  • Medicinal & Biomolecular Chemistry
  • Indoles
  • Humans
  • Biological Availability
  • Animals
  • 3405 Organic chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Henke, B. R., Adkison, K. K., Blanchard, S. G., Leesnitzer, L. M., Mook, R. A., Plunket, K. D., … Willson, T. M. (1999). Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett, 9(23), 3329–3334. https://doi.org/10.1016/s0960-894x(99)00603-4
Henke, B. R., K. K. Adkison, S. G. Blanchard, L. M. Leesnitzer, R. A. Mook, K. D. Plunket, J. A. Ray, C. Roberson, R. Unwalla, and T. M. Willson. “Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.Bioorg Med Chem Lett 9, no. 23 (December 6, 1999): 3329–34. https://doi.org/10.1016/s0960-894x(99)00603-4.
Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA, Plunket KD, et al. Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329–34.
Henke, B. R., et al. “Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.Bioorg Med Chem Lett, vol. 9, no. 23, Dec. 1999, pp. 3329–34. Pubmed, doi:10.1016/s0960-894x(99)00603-4.
Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA, Plunket KD, Ray JA, Roberson C, Unwalla R, Willson TM. Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329–3334.
Journal cover image

Published In

Bioorg Med Chem Lett

DOI

ISSN

0960-894X

Publication Date

December 6, 1999

Volume

9

Issue

23

Start / End Page

3329 / 3334

Location

England

Related Subject Headings

  • Transcription Factors
  • Structure-Activity Relationship
  • Receptors, Cytoplasmic and Nuclear
  • Rats
  • Medicinal & Biomolecular Chemistry
  • Indoles
  • Humans
  • Biological Availability
  • Animals
  • 3405 Organic chemistry