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Lipid-coated microgels for the triggered release of doxorubicin.

Publication ,  Journal Article
Kiser, PF; Wilson, G; Needham, D
Published in: Journal of controlled release : official journal of the Controlled Release Society
July 2000

We have systematically engineered a polymeric, multi-component drug delivery system composed of a lipid-coated hydrogel microparticle (microgel). The design of this delivery system was motivated by the recent elucidation of the mechanism of regulated secretion from the secretory granule and the compositional and structural features that underlie its ability to store and release endogenous drug-like compounds. The present work describes the assembly and response of a prototype construct which displays several important features of the secretory granule, including its high drug loading capacity, and triggered microgel swelling, resulting in the burst release of drug. To achieve this, ionic microgels were synthesized, and loaded with doxorubicin via ion exchange. These microgels were then coated with a lipid bilayer, and the release of doxorubicin was triggered from the gels using either lipid-solubilizing surfactants or electroporation. The use of a microanalytical technique is featured utilizing micropipette manipulation that allows the study of the behavior of individual microparticles. The lipid-coated microgels were electroporated in saline solution; they swelled and disrupted their bilayer coating over a period of several seconds and exchanged doxorubicin with the external plasma saline over a period of several minutes. It is envisioned that this system will ultimately find utility in drug delivery systems that are designed to release chemotherapeutic agents and peptides by the application of a triggering signal.

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Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

July 2000

Volume

68

Issue

1

Start / End Page

9 / 22

Related Subject Headings

  • Pharmacology & Pharmacy
  • Lipid Bilayers
  • Hydrogen-Ion Concentration
  • Hydrogels
  • Drug Delivery Systems
  • Doxorubicin
  • Delayed-Action Preparations
  • Cytoplasmic Granules
  • Antineoplastic Agents
  • 4003 Biomedical engineering
 

Citation

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Kiser, P. F., Wilson, G., & Needham, D. (2000). Lipid-coated microgels for the triggered release of doxorubicin. Journal of Controlled Release : Official Journal of the Controlled Release Society, 68(1), 9–22. https://doi.org/10.1016/s0168-3659(00)00236-4
Kiser, P. F., G. Wilson, and D. Needham. “Lipid-coated microgels for the triggered release of doxorubicin.Journal of Controlled Release : Official Journal of the Controlled Release Society 68, no. 1 (July 2000): 9–22. https://doi.org/10.1016/s0168-3659(00)00236-4.
Kiser PF, Wilson G, Needham D. Lipid-coated microgels for the triggered release of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society. 2000 Jul;68(1):9–22.
Kiser, P. F., et al. “Lipid-coated microgels for the triggered release of doxorubicin.Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 68, no. 1, July 2000, pp. 9–22. Epmc, doi:10.1016/s0168-3659(00)00236-4.
Kiser PF, Wilson G, Needham D. Lipid-coated microgels for the triggered release of doxorubicin. Journal of controlled release : official journal of the Controlled Release Society. 2000 Jul;68(1):9–22.
Journal cover image

Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

July 2000

Volume

68

Issue

1

Start / End Page

9 / 22

Related Subject Headings

  • Pharmacology & Pharmacy
  • Lipid Bilayers
  • Hydrogen-Ion Concentration
  • Hydrogels
  • Drug Delivery Systems
  • Doxorubicin
  • Delayed-Action Preparations
  • Cytoplasmic Granules
  • Antineoplastic Agents
  • 4003 Biomedical engineering