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Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol).

Publication ,  Journal Article
Needham, D; Mills, J; Eichenbaum, G
Published in: Faraday discussions
January 1998

The exchange of the protonatable polymer, poly(2-ethylacrylic acid) (PEAA), has been studied with vesicle membranes containing cholesterol from 0 to 60 mol% or PEG2000-lipid (5 mol%). The release of an entrapped dye from 100 nm extruded liposomes was used as an assay for membrane perturbation by the polymer as a function of pH. The inclusion of cholesterol was found to reduce the pH at which the polymer caused release of the dye from the lipid vesicles, and the degree of polymer protonation (i.e., degree of hydrophobicity) correlated well with the increase in elastic expansion modulus of the vesicle bilayer. The results are discussed in terms of a balance between polymer solubility and membrane expansion. With respect to the PEG barrier, the presence of 5 mol% PEG2000, which represents full surface coverage, did not prevent PEAA from inducing contents release, demonstrating that highly hydrated polymeric layers are not effective barriers for other water soluble polymers, and may point to some association between the two polymers.

Duke Scholars

Published In

Faraday discussions

DOI

EISSN

1364-5498

ISSN

1359-6640

Publication Date

January 1998

Issue

111

Start / End Page

103 / 110

Related Subject Headings

  • Polyethylene Glycols
  • Liposomes
  • Lipid Bilayers
  • Cholesterol
  • Chemical Physics
  • Acrylates
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

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Needham, D., Mills, J., & Eichenbaum, G. (1998). Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol). Faraday Discussions, (111), 103–110. https://doi.org/10.1039/a808717b
Needham, D., J. Mills, and G. Eichenbaum. “Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol).Faraday Discussions, no. 111 (January 1998): 103–10. https://doi.org/10.1039/a808717b.
Needham, D., et al. “Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol).Faraday Discussions, no. 111, Jan. 1998, pp. 103–10. Epmc, doi:10.1039/a808717b.
Journal cover image

Published In

Faraday discussions

DOI

EISSN

1364-5498

ISSN

1359-6640

Publication Date

January 1998

Issue

111

Start / End Page

103 / 110

Related Subject Headings

  • Polyethylene Glycols
  • Liposomes
  • Lipid Bilayers
  • Cholesterol
  • Chemical Physics
  • Acrylates
  • 34 Chemical sciences
  • 03 Chemical Sciences