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Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning.

Publication ,  Journal Article
Cohen, D; Nicolelis, MAL
Published in: J Neurosci
April 7, 2004

Motor skill learning is usually characterized by shortening of response time and performance of faster, more stereotypical movements. However, little is known about the changes in neural activity that underlie these behavioral changes. Here we used chronically implanted electrode arrays to record neuronal activity in the rat primary motor cortex (MI) as animals learned to execute movements in two directions. Strong modulation of MI single-neuron activity was observed while movement duration of the animal decreased. Despite many learning-induced changes, the precision with which single neurons fire did not improve with learning. Hence, prediction of movement direction from single neurons was bounded. In contrast, prediction of movement direction using neuronal ensembles improved significantly with learning, suggesting that, with practice, neuronal ensembles learn to overcome the uncertainty introduced by single-neuron stochastic activity.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 7, 2004

Volume

24

Issue

14

Start / End Page

3574 / 3582

Location

United States

Related Subject Headings

  • Stochastic Processes
  • Reaction Time
  • Rats
  • Predictive Value of Tests
  • Neurons
  • Neurology & Neurosurgery
  • Movement
  • Motor Skills
  • Motor Cortex
  • Models, Neurological
 

Citation

APA
Chicago
ICMJE
MLA
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Cohen, D., & Nicolelis, M. A. L. (2004). Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning. J Neurosci, 24(14), 3574–3582. https://doi.org/10.1523/JNEUROSCI.5361-03.2004
Cohen, Dana, and Miguel A. L. Nicolelis. “Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning.J Neurosci 24, no. 14 (April 7, 2004): 3574–82. https://doi.org/10.1523/JNEUROSCI.5361-03.2004.
Cohen D, Nicolelis MAL. Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning. J Neurosci. 2004 Apr 7;24(14):3574–82.
Cohen, Dana, and Miguel A. L. Nicolelis. “Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning.J Neurosci, vol. 24, no. 14, Apr. 2004, pp. 3574–82. Pubmed, doi:10.1523/JNEUROSCI.5361-03.2004.
Cohen D, Nicolelis MAL. Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning. J Neurosci. 2004 Apr 7;24(14):3574–3582.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 7, 2004

Volume

24

Issue

14

Start / End Page

3574 / 3582

Location

United States

Related Subject Headings

  • Stochastic Processes
  • Reaction Time
  • Rats
  • Predictive Value of Tests
  • Neurons
  • Neurology & Neurosurgery
  • Movement
  • Motor Skills
  • Motor Cortex
  • Models, Neurological