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Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.

Publication ,  Journal Article
Bertagnolli, MM; Redston, M; Compton, CC; Niedzwiecki, D; Mayer, RJ; Goldberg, RM; Colacchio, TA; Saltz, LB; Warren, RS
Published in: J Clin Oncol
August 10, 2011

PURPOSE: Colorectal cancer (CRC) develops as a result of a series of accumulated genomic changes that produce oncogene activation and tumor suppressor gene loss. These characteristics may classify CRC into subsets of distinct clinical behaviors. PATIENTS AND METHODS: We studied two of these genomic defects-mismatch repair deficiency (MMR-D) and loss of heterozygosity at chromosomal location 18q (18qLOH)-in patients enrolled onto two phase III cooperative group trials for treatment of potentially curable colon cancer. These trials included prospective secondary analyses to determine the relationship between these markers and treatment outcome. A total of 1,852 patients were tested for MMR status and 955 (excluding patients with MMR-D tumors) for 18qLOH. RESULTS: Compared with stage III, more stage II tumors were MMR-D (21.3% v 14.4%; P < .001) and were intact at 18q (24.2% v 15.1%; P = .001). For the combined cohort, patients with MMR-D tumors had better 5-year disease-free survival (DFS; 0.76 v 0.67; P < .001) and overall survival (OS; 0.81 v 0.78; P = .029) than those with MMR intact (MMR-I) tumors. Among patients with MMR-I tumors, the status of 18q did not affect outcome, with 5-year values for patients with 18q intact versus 18qLOH tumors of 0.74 versus 0.65 (P = .18) for DFS and 0.81 versus 0.77 (P = .18) for OS. CONCLUSION: We conclude that MMR-D tumor status, but not the presence of 18qLOH, has prognostic value for stages II and III colon cancer.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 10, 2011

Volume

29

Issue

23

Start / End Page

3153 / 3162

Location

United States

Related Subject Headings

  • Proportional Hazards Models
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Microsatellite Instability
  • Male
  • Loss of Heterozygosity
  • Kaplan-Meier Estimate
  • Humans
  • Female
 

Citation

APA
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Bertagnolli, M. M., Redston, M., Compton, C. C., Niedzwiecki, D., Mayer, R. J., Goldberg, R. M., … Warren, R. S. (2011). Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803. J Clin Oncol, 29(23), 3153–3162. https://doi.org/10.1200/JCO.2010.33.0092
Bertagnolli, Monica M., Mark Redston, Carolyn C. Compton, Donna Niedzwiecki, Robert J. Mayer, Richard M. Goldberg, Thomas A. Colacchio, Leonard B. Saltz, and Robert S. Warren. “Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.J Clin Oncol 29, no. 23 (August 10, 2011): 3153–62. https://doi.org/10.1200/JCO.2010.33.0092.
Bertagnolli MM, Redston M, Compton CC, Niedzwiecki D, Mayer RJ, Goldberg RM, et al. Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803. J Clin Oncol. 2011 Aug 10;29(23):3153–62.
Bertagnolli, Monica M., et al. “Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.J Clin Oncol, vol. 29, no. 23, Aug. 2011, pp. 3153–62. Pubmed, doi:10.1200/JCO.2010.33.0092.
Bertagnolli MM, Redston M, Compton CC, Niedzwiecki D, Mayer RJ, Goldberg RM, Colacchio TA, Saltz LB, Warren RS. Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803. J Clin Oncol. 2011 Aug 10;29(23):3153–3162.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 10, 2011

Volume

29

Issue

23

Start / End Page

3153 / 3162

Location

United States

Related Subject Headings

  • Proportional Hazards Models
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Microsatellite Instability
  • Male
  • Loss of Heterozygosity
  • Kaplan-Meier Estimate
  • Humans
  • Female