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One-year cardiovascular event rates in outpatients with atherothrombosis.

Publication ,  Journal Article
Steg, PG; Bhatt, DL; Wilson, PWF; D'Agostino, R; Ohman, EM; Röther, J; Liau, C-S; Hirsch, AT; Mas, J-L; Ikeda, Y; Pencina, MJ; Goto, S ...
Published in: JAMA
March 21, 2007

CONTEXT: Few data document current cardiovascular (CV) event rates in stable patients with atherothrombosis in a community setting. Differential event rates for patients with documented coronary artery disease (CAD), cerebrovascular disease (CVD), or peripheral arterial disease (PAD) or those at risk of these diseases have not been previously evaluated in a single international cohort. OBJECTIVE: To establish contemporary, international, 1-year CV event rates in outpatients with established arterial disease or with multiple risk factors for atherothrombosis. DESIGN, SETTING, AND PARTICIPANTS: The Reduction of Atherothrombosis for Continued Health (REACH) Registry is an international, prospective cohort of 68 236 patients with either established atherosclerotic arterial disease (CAD, PAD, CVD; n = 55 814) or at least 3 risk factors for atherothrombosis (n = 12 422), who were enrolled from 5587 physician practices in 44 countries in 2003-2004. MAIN OUTCOME MEASURES: Rates of CV death, myocardial infarction (MI), and stroke. RESULTS: As of July 2006, 1-year outcomes were available for 95.22% (n = 64 977) of participants. Cardiovascular death, MI, or stroke rates were 4.24% overall: 4.69% for those with established atherosclerotic arterial disease vs 2.15% for patients with multiple risk factors only. Among patients with established disease, CV death, MI, or stroke rates were 4.52% for patients with CAD, 6.47% for patients with CVD, and 5.35% for patients with PAD. The incidences of the end point of CV death, MI, or stroke or of hospitalization for atherothrombotic event(s) were 15.20% for CAD, 14.53% for CVD, and 21.14% for PAD patients with established disease. These event rates increased with the number of symptomatic arterial disease locations, ranging from 5.31% for patients with risk factors only to 12.58% for patients with 1, 21.14% for patients with 2, and 26.27% for patients with 3 symptomatic arterial disease locations (P<.001 for trend). CONCLUSIONS: In this large, contemporary, international study, outpatients with established atherosclerotic arterial disease, or at risk of atherothrombosis, experienced relatively high annual CV event rates. Multiple disease locations increased the 1-year risk of CV events.

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Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

March 21, 2007

Volume

297

Issue

11

Start / End Page

1197 / 1206

Location

United States

Related Subject Headings

  • Thrombosis
  • Stroke
  • Risk Factors
  • Registries
  • Proportional Hazards Models
  • Outpatients
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Steg, P. G., Bhatt, D. L., Wilson, P. W. F., D’Agostino, R., Ohman, E. M., Röther, J., … REACH Registry Investigators, . (2007). One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA, 297(11), 1197–1206. https://doi.org/10.1001/jama.297.11.1197
Steg, Ph Gabriel, Deepak L. Bhatt, Peter W. F. Wilson, Ralph D’Agostino, E Magnus Ohman, Joachim Röther, Chiau-Suong Liau, et al. “One-year cardiovascular event rates in outpatients with atherothrombosis.JAMA 297, no. 11 (March 21, 2007): 1197–1206. https://doi.org/10.1001/jama.297.11.1197.
Steg PG, Bhatt DL, Wilson PWF, D’Agostino R, Ohman EM, Röther J, et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007 Mar 21;297(11):1197–206.
Steg, Ph Gabriel, et al. “One-year cardiovascular event rates in outpatients with atherothrombosis.JAMA, vol. 297, no. 11, Mar. 2007, pp. 1197–206. Pubmed, doi:10.1001/jama.297.11.1197.
Steg PG, Bhatt DL, Wilson PWF, D’Agostino R, Ohman EM, Röther J, Liau C-S, Hirsch AT, Mas J-L, Ikeda Y, Pencina MJ, Goto S, REACH Registry Investigators. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007 Mar 21;297(11):1197–1206.
Journal cover image

Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

March 21, 2007

Volume

297

Issue

11

Start / End Page

1197 / 1206

Location

United States

Related Subject Headings

  • Thrombosis
  • Stroke
  • Risk Factors
  • Registries
  • Proportional Hazards Models
  • Outpatients
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate