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Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells.

Publication ,  Journal Article
Tsuchiya, T; Tsuno, NH; Asakage, M; Yamada, J; Yoneyama, S; Okaji, Y; Sasaki, S; Kitayama, J; Osada, T; Takahashi, K; Nagawa, H
Published in: Hepatogastroenterology
2008

BACKGROUND/AIMS: The p38 mitogen-activated protein kinases (p38 MAPKs) function in a wide variety of signaling pathways. However, the role of p38s is cell type- and stimulus-dependent. The present study aimed to evaluate the effects of p38 MAPK inhibitor on human colon cancer cells. METHODOLOGY: The effect of p38 MAPK inhibitor, FR167653, on DLD-1 and SW480 was investigated related to cell proliferation, apoptosis induction and caspase activity. Additionally, the effect of FR167653 on colon cancer cell migration, MMPs production and ability to adhere to extracellular matrix was investigated. RESULTS: Inhibitor of p38 MAPK dose-dependently suppressed the proliferative activity of both cell lines, and increased the induction of cell apoptosis. The caspase-3, 8, and 9 activities were accompanied in the pathway. Neither cell migration, MMPs production, nor the ability to adhere extracellular matrix were affected by FR167653. CONCLUSIONS: Inhibitor of p38 MAPK suppressed the proliferation of colon cancer cells by induction of cell apoptosis through the caspase activation. The present results suggest the pro-oncogenic role ofp38 in colon cancer, and its inhibition would be a novel strategy for the prevention and treatment of colon cancer.

Duke Scholars

Published In

Hepatogastroenterology

ISSN

0172-6390

Publication Date

2008

Volume

55

Issue

84

Start / End Page

930 / 935

Location

Greece

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Tumor Cells, Cultured
  • Pyridines
  • Pyrazoles
  • Humans
  • Gastroenterology & Hepatology
  • Colonic Neoplasms
  • Cell Movement
  • Cell Division
  • Cell Adhesion
 

Citation

APA
Chicago
ICMJE
MLA
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Tsuchiya, T., Tsuno, N. H., Asakage, M., Yamada, J., Yoneyama, S., Okaji, Y., … Nagawa, H. (2008). Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells. Hepatogastroenterology, 55(84), 930–935.
Tsuchiya, Takeshi, Nelson H. Tsuno, Masahiro Asakage, Jun Yamada, Satomi Yoneyama, Yurai Okaji, Shin Sasaki, et al. “Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells.Hepatogastroenterology 55, no. 84 (2008): 930–35.
Tsuchiya T, Tsuno NH, Asakage M, Yamada J, Yoneyama S, Okaji Y, et al. Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells. Hepatogastroenterology. 2008;55(84):930–5.
Tsuchiya, Takeshi, et al. “Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells.Hepatogastroenterology, vol. 55, no. 84, 2008, pp. 930–35.
Tsuchiya T, Tsuno NH, Asakage M, Yamada J, Yoneyama S, Okaji Y, Sasaki S, Kitayama J, Osada T, Takahashi K, Nagawa H. Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells. Hepatogastroenterology. 2008;55(84):930–935.
Journal cover image

Published In

Hepatogastroenterology

ISSN

0172-6390

Publication Date

2008

Volume

55

Issue

84

Start / End Page

930 / 935

Location

Greece

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Tumor Cells, Cultured
  • Pyridines
  • Pyrazoles
  • Humans
  • Gastroenterology & Hepatology
  • Colonic Neoplasms
  • Cell Movement
  • Cell Division
  • Cell Adhesion