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Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa.

Publication ,  Journal Article
Nishioka, K; Grossie, VB; Chang, TH; Ajani, JA; Ota, DM
Published in: J Surg Oncol
June 1991

To examine the value of ornithine decarboxylase (ODC) assay as a biological marker of potential malignancy in large bowel, we harvested 43 colorectal carcinoma, 7 adenoma, 6 polyps, and 77 normal-appearing mucosa at surgery from patients with colorectal carcinoma. In addition, 13 normal rectal mucosa were obtained at biopsy from patients with benign diseases or diseases unrelated to colorectal carcinoma as normal control. ODC activity was significantly higher in polyps and adenocarcinomas than in normal-appearing mucosa from patients with colorectal carcinoma. ODC activity in normal-appearing mucosa varied throughout the large intestine, with significantly higher activities in the distal segment of the large bowel. The higher ODC activity detected in the sigmoid colon and rectum correlates with the larger incidence of tumor development in this region of the large bowel. This observation needs to be taken into consideration when ODC activities of the colorectal mucosa are measured as biological markers of potential malignancies.

Duke Scholars

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

June 1991

Volume

47

Issue

2

Start / End Page

117 / 120

Location

United States

Related Subject Headings

  • Ornithine Decarboxylase
  • Oncology & Carcinogenesis
  • Intestine, Large
  • Intestinal Polyps
  • Intestinal Mucosa
  • Humans
  • Colorectal Neoplasms
  • Carcinoma
  • Adenoma
  • 3211 Oncology and carcinogenesis
 

Citation

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MLA
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Nishioka, K., Grossie, V. B., Chang, T. H., Ajani, J. A., & Ota, D. M. (1991). Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa. J Surg Oncol, 47(2), 117–120. https://doi.org/10.1002/jso.2930470211
Nishioka, K., V. B. Grossie, T. H. Chang, J. A. Ajani, and D. M. Ota. “Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa.J Surg Oncol 47, no. 2 (June 1991): 117–20. https://doi.org/10.1002/jso.2930470211.
Nishioka K, Grossie VB, Chang TH, Ajani JA, Ota DM. Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa. J Surg Oncol. 1991 Jun;47(2):117–20.
Nishioka, K., et al. “Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa.J Surg Oncol, vol. 47, no. 2, June 1991, pp. 117–20. Pubmed, doi:10.1002/jso.2930470211.
Nishioka K, Grossie VB, Chang TH, Ajani JA, Ota DM. Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa. J Surg Oncol. 1991 Jun;47(2):117–120.
Journal cover image

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

June 1991

Volume

47

Issue

2

Start / End Page

117 / 120

Location

United States

Related Subject Headings

  • Ornithine Decarboxylase
  • Oncology & Carcinogenesis
  • Intestine, Large
  • Intestinal Polyps
  • Intestinal Mucosa
  • Humans
  • Colorectal Neoplasms
  • Carcinoma
  • Adenoma
  • 3211 Oncology and carcinogenesis