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Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial.

Publication ,  Journal Article
Perlman, AI; Ali, A; Njike, VY; Hom, D; Davidi, A; Gould-Fogerite, S; Milak, C; Katz, DL
Published in: PLoS One
2012

BACKGROUND: In a previous trial of massage for osteoarthritis (OA) of the knee, we demonstrated feasibility, safety and possible efficacy, with benefits that persisted at least 8 weeks beyond treatment termination. METHODS: We performed a RCT to identify the optimal dose of massage within an 8-week treatment regimen and to further examine durability of response. Participants were 125 adults with OA of the knee, randomized to one of four 8-week regimens of a standardized Swedish massage regimen (30 or 60 min weekly or biweekly) or to a Usual Care control. Outcomes included the Western Ontario and McMaster Universities Arthritis Index (WOMAC), visual analog pain scale, range of motion, and time to walk 50 feet, assessed at baseline, 8-, 16-, and 24-weeks. RESULTS: WOMAC Global scores improved significantly (24.0 points, 95% CI ranged from 15.3-32.7) in the 60-minute massage groups compared to Usual Care (6.3 points, 95% CI 0.1-12.8) at the primary endpoint of 8-weeks. WOMAC subscales of pain and functionality, as well as the visual analog pain scale also demonstrated significant improvements in the 60-minute doses compared to usual care. No significant differences were seen in range of motion at 8-weeks, and no significant effects were seen in any outcome measure at 24-weeks compared to usual care. A dose-response curve based on WOMAC Global scores shows increasing effect with greater total time of massage, but with a plateau at the 60-minute/week dose. CONCLUSION: Given the superior convenience of a once-weekly protocol, cost savings, and consistency with a typical real-world massage protocol, the 60-minute once weekly dose was determined to be optimal, establishing a standard for future trials. TRIAL REGISTRATION: ClinicalTrials.gov NCT00970008.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

2

Start / End Page

e30248

Location

United States

Related Subject Headings

  • Walking
  • Treatment Outcome
  • Time Factors
  • Range of Motion, Articular
  • Pain Measurement
  • Osteoarthritis, Knee
  • Middle Aged
  • Massage
  • Male
  • Humans
 

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Perlman, A. I., Ali, A., Njike, V. Y., Hom, D., Davidi, A., Gould-Fogerite, S., … Katz, D. L. (2012). Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial. PLoS One, 7(2), e30248. https://doi.org/10.1371/journal.pone.0030248
Perlman, Adam I., Ather Ali, Valentine Yanchou Njike, David Hom, Anna Davidi, Susan Gould-Fogerite, Carl Milak, and David L. Katz. “Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial.PLoS One 7, no. 2 (2012): e30248. https://doi.org/10.1371/journal.pone.0030248.
Perlman AI, Ali A, Njike VY, Hom D, Davidi A, Gould-Fogerite S, et al. Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial. PLoS One. 2012;7(2):e30248.
Perlman, Adam I., et al. “Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial.PLoS One, vol. 7, no. 2, 2012, p. e30248. Pubmed, doi:10.1371/journal.pone.0030248.
Perlman AI, Ali A, Njike VY, Hom D, Davidi A, Gould-Fogerite S, Milak C, Katz DL. Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial. PLoS One. 2012;7(2):e30248.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

2

Start / End Page

e30248

Location

United States

Related Subject Headings

  • Walking
  • Treatment Outcome
  • Time Factors
  • Range of Motion, Articular
  • Pain Measurement
  • Osteoarthritis, Knee
  • Middle Aged
  • Massage
  • Male
  • Humans