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The role of microparticles in the generation of immune complexes in murine lupus.

Publication ,  Journal Article
Ullal, AJ; Pisetsky, DS
Published in: Clin Immunol
January 2013

Systemic lupus erythematosus is a systemic inflammatory disease characterized by antibodies to nuclear molecules in association with immune complex deposition. As shown previously, microparticles (MPs), which are small membrane-bound vesicles released from dying and activated cells, contain nucleic acids and can form immune complexes found in patient blood. To assess the role of MPs in murine lupus, we used flow cytometry to measure the presence of MPs with bound IgG in the blood of MRL-lpr/lpr and NZB/W mice. These studies showed much higher numbers of MPs with bound IgG in the blood of MRL lpr/lpr compared to NZB/W mice. Furthermore, these studies showed that antibodies from MRL-lpr/lpr mice bound better to MPs from apoptotic cells than those from NZB/W mice. Together, these studies indicate important differences in the serological features of the two strains as reflected by the capacity of antibodies to bind to MPs.

Duke Scholars

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

January 2013

Volume

146

Issue

1

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Time Factors
  • Species Specificity
  • Protein Binding
  • Mice, Inbred NZB
  • Mice, Inbred MRL lpr
  • Mice, Inbred BALB C
  • Mice
  • Lupus Erythematosus, Systemic
  • Jurkat Cells
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ullal, A. J., & Pisetsky, D. S. (2013). The role of microparticles in the generation of immune complexes in murine lupus. Clin Immunol, 146(1), 1–9. https://doi.org/10.1016/j.clim.2012.10.004
Ullal, Anirudh J., and David S. Pisetsky. “The role of microparticles in the generation of immune complexes in murine lupus.Clin Immunol 146, no. 1 (January 2013): 1–9. https://doi.org/10.1016/j.clim.2012.10.004.
Ullal AJ, Pisetsky DS. The role of microparticles in the generation of immune complexes in murine lupus. Clin Immunol. 2013 Jan;146(1):1–9.
Ullal, Anirudh J., and David S. Pisetsky. “The role of microparticles in the generation of immune complexes in murine lupus.Clin Immunol, vol. 146, no. 1, Jan. 2013, pp. 1–9. Pubmed, doi:10.1016/j.clim.2012.10.004.
Ullal AJ, Pisetsky DS. The role of microparticles in the generation of immune complexes in murine lupus. Clin Immunol. 2013 Jan;146(1):1–9.
Journal cover image

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

January 2013

Volume

146

Issue

1

Start / End Page

1 / 9

Location

United States

Related Subject Headings

  • Time Factors
  • Species Specificity
  • Protein Binding
  • Mice, Inbred NZB
  • Mice, Inbred MRL lpr
  • Mice, Inbred BALB C
  • Mice
  • Lupus Erythematosus, Systemic
  • Jurkat Cells
  • Immunology