Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.

Publication ,  Journal Article
Harrill, AH; Roach, J; Fier, I; Eaddy, JS; Kurtz, CL; Antoine, DJ; Spencer, DM; Kishimoto, TK; Pisetsky, DS; Park, BK; Watkins, PB
Published in: Clin Pharmacol Ther
August 2012

Heparins have been reported to cause elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) but have not been associated with clinically significant liver injury. The mechanisms underlying these benign laboratory abnormalities are unknown. Forty-eight healthy men were randomized to receive subcutaneous injections of unfractionated heparin (UFH; 150 U/kg), enoxaparin sodium (1 mg/kg), dalteparin sodium (120 IU/kg), or adomiparin sodium (125 IU/kg; a novel heparin) every 12 h for 4.5 days. Asymptomatic elevations in serum ALT or AST were observed in >90% of the subjects. Elevations were also observed in the levels of serum sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GLDH), miR-122, high-mobility group box-1 protein (including the acetylated form), full-length keratin 18, and DNA. Keratin 18 fragments, which are apoptosis biomarkers, were not detected. Biomarker profiles did not differ significantly across heparin treatments. We conclude that heparins as a class cause self-limited and mild hepatocyte necrosis with secondary activation of an innate immune response.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

August 2012

Volume

92

Issue

2

Start / End Page

214 / 220

Location

United States

Related Subject Headings

  • Young Adult
  • Pharmacology & Pharmacy
  • Middle Aged
  • MicroRNAs
  • Male
  • Liver
  • L-Iditol 2-Dehydrogenase
  • Keratin-18
  • Humans
  • Heparin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harrill, A. H., Roach, J., Fier, I., Eaddy, J. S., Kurtz, C. L., Antoine, D. J., … Watkins, P. B. (2012). The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clin Pharmacol Ther, 92(2), 214–220. https://doi.org/10.1038/clpt.2012.40
Harrill, A. H., J. Roach, I. Fier, J. S. Eaddy, C. L. Kurtz, D. J. Antoine, D. M. Spencer, et al. “The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.Clin Pharmacol Ther 92, no. 2 (August 2012): 214–20. https://doi.org/10.1038/clpt.2012.40.
Harrill AH, Roach J, Fier I, Eaddy JS, Kurtz CL, Antoine DJ, et al. The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clin Pharmacol Ther. 2012 Aug;92(2):214–20.
Harrill, A. H., et al. “The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.Clin Pharmacol Ther, vol. 92, no. 2, Aug. 2012, pp. 214–20. Pubmed, doi:10.1038/clpt.2012.40.
Harrill AH, Roach J, Fier I, Eaddy JS, Kurtz CL, Antoine DJ, Spencer DM, Kishimoto TK, Pisetsky DS, Park BK, Watkins PB. The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clin Pharmacol Ther. 2012 Aug;92(2):214–220.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

August 2012

Volume

92

Issue

2

Start / End Page

214 / 220

Location

United States

Related Subject Headings

  • Young Adult
  • Pharmacology & Pharmacy
  • Middle Aged
  • MicroRNAs
  • Male
  • Liver
  • L-Iditol 2-Dehydrogenase
  • Keratin-18
  • Humans
  • Heparin