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HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.

Publication ,  Journal Article
Harris, HE; Andersson, U; Pisetsky, DS
Published in: Nat Rev Rheumatol
January 31, 2012

HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the pathogenesis of inflammatory and autoimmune disease. Although primarily located in the cell nucleus, HMGB1 can translocate to the cytoplasm, as well as the extracellular space, during cell activation and cell death; during activation, HMGB1 can undergo post-translational modifications. The activity of HMGB1 varies with the redox states of the cysteine residues, which are required for binding to TLR4. In addition to stimulating cells directly, HMGB1 can form immunostimulatory complexes with cytokines and other endogenous and exogenous factors. In the synovia of patients with rheumatoid arthritis, as well as animal models of this disease, extranuclear expression of HMGB1 is increased and blockade of HMGB1 expression attenuates disease in animal models. In systemic lupus erythematosus, HMGB1 can be a component of immune complexes containing anti-DNA because of its interaction with DNA. In myositis, expression of HMGB1 is enhanced in inflamed muscle and can perturb muscle function. Together, these findings indicate that HMGB1 might be an important mediator and biomarker in rheumatic diseases as well as a target of new therapy.

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Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

January 31, 2012

Volume

8

Issue

4

Start / End Page

195 / 202

Location

United States

Related Subject Headings

  • Signal Transduction
  • Rheumatic Diseases
  • Inflammation
  • Humans
  • HMGB1 Protein
  • DNA-Binding Proteins
  • Autoimmune Diseases
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Harris, H. E., Andersson, U., & Pisetsky, D. S. (2012). HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol, 8(4), 195–202. https://doi.org/10.1038/nrrheum.2011.222
Harris, Helena Erlandsson, Ulf Andersson, and David S. Pisetsky. “HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.Nat Rev Rheumatol 8, no. 4 (January 31, 2012): 195–202. https://doi.org/10.1038/nrrheum.2011.222.
Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol. 2012 Jan 31;8(4):195–202.
Harris, Helena Erlandsson, et al. “HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.Nat Rev Rheumatol, vol. 8, no. 4, Jan. 2012, pp. 195–202. Pubmed, doi:10.1038/nrrheum.2011.222.
Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol. 2012 Jan 31;8(4):195–202.

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

January 31, 2012

Volume

8

Issue

4

Start / End Page

195 / 202

Location

United States

Related Subject Headings

  • Signal Transduction
  • Rheumatic Diseases
  • Inflammation
  • Humans
  • HMGB1 Protein
  • DNA-Binding Proteins
  • Autoimmune Diseases
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences