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Cardiac regenerative capacity and mechanisms.

Publication ,  Journal Article
Kikuchi, K; Poss, KD
Published in: Annu Rev Cell Dev Biol
2012

The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide vulnerable to heart failure each year. By contrast, certain other vertebrate species such as zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms and advances in methodology to transplant cells together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review focuses on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained.

Duke Scholars

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Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

2012

Volume

28

Start / End Page

719 / 741

Location

United States

Related Subject Headings

  • Stem Cells
  • Regenerative Medicine
  • Regeneration
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Humans
  • Heart
  • Disease Models, Animal
  • Developmental Biology
  • Cell Proliferation
 

Citation

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Kikuchi, K., & Poss, K. D. (2012). Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol, 28, 719–741. https://doi.org/10.1146/annurev-cellbio-101011-155739
Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac regenerative capacity and mechanisms.Annu Rev Cell Dev Biol 28 (2012): 719–41. https://doi.org/10.1146/annurev-cellbio-101011-155739.
Kikuchi K, Poss KD. Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol. 2012;28:719–41.
Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac regenerative capacity and mechanisms.Annu Rev Cell Dev Biol, vol. 28, 2012, pp. 719–41. Pubmed, doi:10.1146/annurev-cellbio-101011-155739.
Kikuchi K, Poss KD. Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol. 2012;28:719–741.

Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

2012

Volume

28

Start / End Page

719 / 741

Location

United States

Related Subject Headings

  • Stem Cells
  • Regenerative Medicine
  • Regeneration
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Humans
  • Heart
  • Disease Models, Animal
  • Developmental Biology
  • Cell Proliferation