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tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.

Publication ,  Journal Article
Kikuchi, K; Gupta, V; Wang, J; Holdway, JE; Wills, AA; Fang, Y; Poss, KD
Published in: Development
July 2011

Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

July 2011

Volume

138

Issue

14

Start / End Page

2895 / 2902

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Transcription Factors
  • Regeneration
  • Pericardium
  • Morphogenesis
  • Heart
  • Gene Expression Regulation, Developmental
  • Fluorescent Antibody Technique
  • Cell Lineage
 

Citation

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Kikuchi, K., Gupta, V., Wang, J., Holdway, J. E., Wills, A. A., Fang, Y., & Poss, K. D. (2011). tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development, 138(14), 2895–2902. https://doi.org/10.1242/dev.067041
Kikuchi, Kazu, Vikas Gupta, Jinhu Wang, Jennifer E. Holdway, Airon A. Wills, Yi Fang, and Kenneth D. Poss. “tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.Development 138, no. 14 (July 2011): 2895–2902. https://doi.org/10.1242/dev.067041.
Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, et al. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development. 2011 Jul;138(14):2895–902.
Kikuchi, Kazu, et al. “tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.Development, vol. 138, no. 14, July 2011, pp. 2895–902. Pubmed, doi:10.1242/dev.067041.
Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, Poss KD. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development. 2011 Jul;138(14):2895–2902.
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

July 2011

Volume

138

Issue

14

Start / End Page

2895 / 2902

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Transcription Factors
  • Regeneration
  • Pericardium
  • Morphogenesis
  • Heart
  • Gene Expression Regulation, Developmental
  • Fluorescent Antibody Technique
  • Cell Lineage