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Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells.

Publication ,  Journal Article
Vitiello, L; Masci, AM; Montella, L; Perna, F; Angelini, DF; Borsellino, G; Battistini, L; Merola, G; De Palma, R; Spadaro, G; Cosentini, E ...
Published in: Int J Immunopathol Pharmacol
2010

Thymomas are rare tumours that sustain T-lymphopoiesis and trigger a variety of autoimmune diseases and immunodeficiencies, including a fatal hypogammaglobulinemia, namely Goods Syndrome (GS). Due to its rarity, GS has been poorly investigated and immunological features, as well as pathogenetic mechanisms underlying this syndrome, are unclear. We studied 30 thymoma patients by performing an immunological assessment, including immunophenotype and analysis of T cell repertoire (TCR). Development of GS was characterized by a progressive decrease in B, CD4 T and NK lymphocytes. These alterations paired with accumulation of CD8+CD45RA+ T cells that showed a polyclonal repertoire without expansions of specific clonotypes. GS is defined as hypogammaglobulinemia with thymoma. Here, we show for the first time that this syndrome is characterized by a severe loss of CD4+, NK and B cells. Furthermore, the accumulation of CD8+CD45RA+ T lymphocytes parallels these changes; this accumulation may have a role in determining the disease and can be used to monitor clinical stages of immunodeficiency in thymoma.

Duke Scholars

Published In

Int J Immunopathol Pharmacol

DOI

ISSN

0394-6320

Publication Date

2010

Volume

23

Issue

1

Start / End Page

307 / 316

Location

England

Related Subject Headings

  • Thymus Neoplasms
  • Thymoma
  • Middle Aged
  • Male
  • Lymphocyte Count
  • Leukocyte Common Antigens
  • Killer Cells, Natural
  • Immunology
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vitiello, L., Masci, A. M., Montella, L., Perna, F., Angelini, D. F., Borsellino, G., … Racioppi, L. (2010). Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells. Int J Immunopathol Pharmacol, 23(1), 307–316. https://doi.org/10.1177/039463201002300129
Vitiello, L., A. M. Masci, L. Montella, F. Perna, D. F. Angelini, G. Borsellino, L. Battistini, et al. “Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells.Int J Immunopathol Pharmacol 23, no. 1 (2010): 307–16. https://doi.org/10.1177/039463201002300129.
Vitiello L, Masci AM, Montella L, Perna F, Angelini DF, Borsellino G, et al. Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells. Int J Immunopathol Pharmacol. 2010;23(1):307–16.
Vitiello, L., et al. “Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells.Int J Immunopathol Pharmacol, vol. 23, no. 1, 2010, pp. 307–16. Pubmed, doi:10.1177/039463201002300129.
Vitiello L, Masci AM, Montella L, Perna F, Angelini DF, Borsellino G, Battistini L, Merola G, De Palma R, Spadaro G, Cosentini E, Palmieri G, Racioppi L. Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells. Int J Immunopathol Pharmacol. 2010;23(1):307–316.
Journal cover image

Published In

Int J Immunopathol Pharmacol

DOI

ISSN

0394-6320

Publication Date

2010

Volume

23

Issue

1

Start / End Page

307 / 316

Location

England

Related Subject Headings

  • Thymus Neoplasms
  • Thymoma
  • Middle Aged
  • Male
  • Lymphocyte Count
  • Leukocyte Common Antigens
  • Killer Cells, Natural
  • Immunology
  • Humans
  • Follow-Up Studies