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Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.

Publication ,  Journal Article
Rezvani, AH; Grady, DR; Peek, AE; Pucilowski, O
Published in: Pharmacol Biochem Behav
February 1995

The effect of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on voluntary alcohol consumption was examined in two different strains of alcohol-preferring rats, in a continuous-access, two-bottle-choice paradigm. Compared with the vehicle, intraperitoneal injections of L-NAME significantly and dose-dependently (10, 30, and 60 mg/kg) suppressed alcohol intake and preference in both alcohol-preferring (P) and Fawn-Hooded (FH) rats. The effect of the highest dose of L-NAME was nonspecific; it caused general decreases in consumption of alcohol, water, and food. Repeated injection of L-NAME (30 mg/kg) for 4 consecutive days significantly attenuated alcohol intake, but tolerance developed after 3 days of treatment. A single administration of a high dose of L-NAME (60 mg/kg) did not influence the blood alcohol concentrations, which suggests a possible central effect. Furthermore, a moderate dose of 30 mg/kg L-NAME, which selectively inhibited alcohol intake, did not exert a significant effect on telemetrically measured heart rate, core body temperature, and gross motor activity of alcohol naive Fawn-Hooded rats. These results suggest an involvement of nitric oxide in alcohol drinking behavior. Although the true mechanism(s) of action is not yet clear, it can be speculated that L-NAME may exert its action indirectly by modulating neurotransmitters proposed to be involved in alcohol drinking and/or by influencing other neuronal factors, such as neuronal Ca2+ channels, which have been shown to be involved in alcohol drinking behavior.

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Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1995

Volume

50

Issue

2

Start / End Page

265 / 270

Location

United States

Related Subject Headings

  • Species Specificity
  • Rats
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Neurology & Neurosurgery
  • NG-Nitroarginine Methyl Ester
  • Motor Activity
  • Male
  • Heart Rate
  • Ethanol
 

Citation

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Rezvani, A. H., Grady, D. R., Peek, A. E., & Pucilowski, O. (1995). Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. Pharmacol Biochem Behav, 50(2), 265–270. https://doi.org/10.1016/0091-3057(94)00310-f
Rezvani, A. H., D. R. Grady, A. E. Peek, and O. Pucilowski. “Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.Pharmacol Biochem Behav 50, no. 2 (February 1995): 265–70. https://doi.org/10.1016/0091-3057(94)00310-f.
Rezvani AH, Grady DR, Peek AE, Pucilowski O. Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. Pharmacol Biochem Behav. 1995 Feb;50(2):265–70.
Rezvani, A. H., et al. “Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.Pharmacol Biochem Behav, vol. 50, no. 2, Feb. 1995, pp. 265–70. Pubmed, doi:10.1016/0091-3057(94)00310-f.
Rezvani AH, Grady DR, Peek AE, Pucilowski O. Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. Pharmacol Biochem Behav. 1995 Feb;50(2):265–270.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1995

Volume

50

Issue

2

Start / End Page

265 / 270

Location

United States

Related Subject Headings

  • Species Specificity
  • Rats
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Neurology & Neurosurgery
  • NG-Nitroarginine Methyl Ester
  • Motor Activity
  • Male
  • Heart Rate
  • Ethanol