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5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism.

Publication ,  Journal Article
Overstreet, DH; Rezvani, AH; Pucilowski, O; Janowsky, DS
Published in: Alcohol Alcohol Suppl
1994

The involvement of serotonergic mechanisms in the neuropharmacology of alcohol was appreciated before it was recognized that there were multiple subtypes of serotonin (5-hydroxytryptamine; 5-HT) receptors. Thus, it was known that manipulations of the central serotonergic system could lead to a modification of the rate of tolerance development to alcohol (Frankel et al., 1975) or to a modulation of alcohol intake (Myers and Martin, 1973; Myers and Melchior, 1975) before Peroutka and Snyder (1979) first suggested that there were at least two subtypes of 5-HT receptors. Since these early reports were written, there has been a wealth of studies which have continued to support a role for 5-HT in the regulation of alcohol intake (See McBride et al., 1993b; Sellers et al., 1992, for reviews). Simultaneously, a tremendous expansion in the number of known 5-HT receptor subtypes has occurred (See Peroutka, 1988). However, there have not been, to our knowledge, any papers which have examined the possible role of specific 5-HT receptor subtypes in the regulation of alcohol's central effects. The present review addresses this deficiency in the literature. This review will focus on three major areas: the pharmacological regulation of alcohol intake; differences in 5-HT receptor subtypes among alcohol-preferring and -nonpreferring rat strains; and alterations in 5-HT receptor subtypes following chronic exposure to alcohol.

Duke Scholars

Published In

Alcohol Alcohol Suppl

ISSN

1358-6173

Publication Date

1994

Volume

2

Start / End Page

205 / 210

Location

England

Related Subject Headings

  • Serotonin Receptor Agonists
  • Serotonin Antagonists
  • Receptors, Serotonin
  • Rats
  • Ethanol
  • Brain
  • Animals
  • Alcoholism
  • Alcohol Drinking
 

Citation

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Chicago
ICMJE
MLA
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Overstreet, D. H., Rezvani, A. H., Pucilowski, O., & Janowsky, D. S. (1994). 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism. Alcohol Alcohol Suppl, 2, 205–210.
Overstreet, D. H., A. H. Rezvani, O. Pucilowski, and D. S. Janowsky. “5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism.Alcohol Alcohol Suppl 2 (1994): 205–10.
Overstreet DH, Rezvani AH, Pucilowski O, Janowsky DS. 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism. Alcohol Alcohol Suppl. 1994;2:205–10.
Overstreet, D. H., et al. “5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism.Alcohol Alcohol Suppl, vol. 2, 1994, pp. 205–10.
Overstreet DH, Rezvani AH, Pucilowski O, Janowsky DS. 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism. Alcohol Alcohol Suppl. 1994;2:205–210.

Published In

Alcohol Alcohol Suppl

ISSN

1358-6173

Publication Date

1994

Volume

2

Start / End Page

205 / 210

Location

England

Related Subject Headings

  • Serotonin Receptor Agonists
  • Serotonin Antagonists
  • Receptors, Serotonin
  • Rats
  • Ethanol
  • Brain
  • Animals
  • Alcoholism
  • Alcohol Drinking