Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.
Publication
, Journal Article
Rezvani, AH; Grady, DR; Janowsky, DS
Published in: Alcohol Alcohol
1991
Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake in all monkeys tested. Chronic treatment with verapamil, but not saline, dose-dependently attenuated alcohol intake, without significantly influencing water intake. These findings suggest that verapamil exerts an inhibitory action on ethanol preference in chronically alcohol-drinking monkeys, possibly by interfering with Ca(2+)-channels and/or by interacting with the activity of certain central neurotransmitters.
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Published In
Alcohol Alcohol
DOI
ISSN
0735-0414
Publication Date
1991
Volume
26
Issue
2
Start / End Page
161 / 167
Location
England
Related Subject Headings
- Verapamil
- Substance Abuse
- Male
- Macaca
- Female
- Dose-Response Relationship, Drug
- Diltiazem
- Calcium Channels
- Brain
- Animals
Citation
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Rezvani, A. H., Grady, D. R., & Janowsky, D. S. (1991). Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys. Alcohol Alcohol, 26(2), 161–167. https://doi.org/10.1093/oxfordjournals.alcalc.a045097
Rezvani, A. H., D. R. Grady, and D. S. Janowsky. “Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.” Alcohol Alcohol 26, no. 2 (1991): 161–67. https://doi.org/10.1093/oxfordjournals.alcalc.a045097.
Rezvani AH, Grady DR, Janowsky DS. Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys. Alcohol Alcohol. 1991;26(2):161–7.
Rezvani, A. H., et al. “Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.” Alcohol Alcohol, vol. 26, no. 2, 1991, pp. 161–67. Pubmed, doi:10.1093/oxfordjournals.alcalc.a045097.
Rezvani AH, Grady DR, Janowsky DS. Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys. Alcohol Alcohol. 1991;26(2):161–167.
Published In
Alcohol Alcohol
DOI
ISSN
0735-0414
Publication Date
1991
Volume
26
Issue
2
Start / End Page
161 / 167
Location
England
Related Subject Headings
- Verapamil
- Substance Abuse
- Male
- Macaca
- Female
- Dose-Response Relationship, Drug
- Diltiazem
- Calcium Channels
- Brain
- Animals