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Mismatch repair proteins and mitotic genome stability.

Publication ,  Journal Article
Harfe, BD; Jinks-Robertson, S
Published in: Mutat Res
June 30, 2000

Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae.

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Published In

Mutat Res

DOI

ISSN

0027-5107

Publication Date

June 30, 2000

Volume

451

Issue

1-2

Start / End Page

151 / 167

Location

Netherlands

Related Subject Headings

  • Yeasts
  • Recombination, Genetic
  • Proteins
  • Proliferating Cell Nuclear Antigen
  • Oncology & Carcinogenesis
  • Mutation
  • MutS DNA Mismatch-Binding Protein
  • MutL Proteins
  • Mitosis
  • Humans
 

Citation

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Harfe, B. D., & Jinks-Robertson, S. (2000). Mismatch repair proteins and mitotic genome stability. Mutat Res, 451(1–2), 151–167. https://doi.org/10.1016/s0027-5107(00)00047-6
Harfe, B. D., and S. Jinks-Robertson. “Mismatch repair proteins and mitotic genome stability.Mutat Res 451, no. 1–2 (June 30, 2000): 151–67. https://doi.org/10.1016/s0027-5107(00)00047-6.
Harfe BD, Jinks-Robertson S. Mismatch repair proteins and mitotic genome stability. Mutat Res. 2000 Jun 30;451(1–2):151–67.
Harfe, B. D., and S. Jinks-Robertson. “Mismatch repair proteins and mitotic genome stability.Mutat Res, vol. 451, no. 1–2, June 2000, pp. 151–67. Pubmed, doi:10.1016/s0027-5107(00)00047-6.
Harfe BD, Jinks-Robertson S. Mismatch repair proteins and mitotic genome stability. Mutat Res. 2000 Jun 30;451(1–2):151–167.
Journal cover image

Published In

Mutat Res

DOI

ISSN

0027-5107

Publication Date

June 30, 2000

Volume

451

Issue

1-2

Start / End Page

151 / 167

Location

Netherlands

Related Subject Headings

  • Yeasts
  • Recombination, Genetic
  • Proteins
  • Proliferating Cell Nuclear Antigen
  • Oncology & Carcinogenesis
  • Mutation
  • MutS DNA Mismatch-Binding Protein
  • MutL Proteins
  • Mitosis
  • Humans