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JNK1 is required to preserve cardiac function in the early response to pressure overload.

Publication ,  Journal Article
Tachibana, H; Perrino, C; Takaoka, H; Davis, RJ; Naga Prasad, SV; Rockman, HA
Published in: Biochem Biophys Res Commun
May 19, 2006

Cardiac stress consistently activates c-Jun NH(2)-terminal kinase (JNK) pathways, however the role of different members of the JNK family is unclear. In this study, we applied pressure overload (TAC) in mice with selective deletion of the three JNK genes (Jnk1(-/-), Jnk2(-/-), and Jnk3(-/-)). Following TAC, all three JNK knockout mouse lines developed cardiac hypertrophy similar to wild-type mice (WT), but only JNK1(-/-) mice displayed a significant reduction in fractional shortening after 3 and 7 days of pressure overload, associated with a significant increase in terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling staining and marked inflammatory infiltrate. After the acute deterioration stage, JNK1(-/-) mice underwent a slow recovery followed by a steady progression of cardiac dysfunction, becoming indistinguishable from WT after 12 weeks of TAC. These data suggest that JNK1 plays a protective role in response to pressure overload, preventing the early deterioration in cardiac function following an acute increase in afterload.

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Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

May 19, 2006

Volume

343

Issue

4

Start / End Page

1060 / 1066

Location

United States

Related Subject Headings

  • Phenotype
  • Myocardium
  • Mitogen-Activated Protein Kinase 9
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinase 10
  • Mice, Knockout
  • Mice
  • Male
  • In Situ Nick-End Labeling
  • Female
 

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Tachibana, H., Perrino, C., Takaoka, H., Davis, R. J., Naga Prasad, S. V., & Rockman, H. A. (2006). JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun, 343(4), 1060–1066. https://doi.org/10.1016/j.bbrc.2006.03.065
Tachibana, Hideo, Cinzia Perrino, Hideyuki Takaoka, Roger J. Davis, Sathyamangla V. Naga Prasad, and Howard A. Rockman. “JNK1 is required to preserve cardiac function in the early response to pressure overload.Biochem Biophys Res Commun 343, no. 4 (May 19, 2006): 1060–66. https://doi.org/10.1016/j.bbrc.2006.03.065.
Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman HA. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun. 2006 May 19;343(4):1060–6.
Tachibana, Hideo, et al. “JNK1 is required to preserve cardiac function in the early response to pressure overload.Biochem Biophys Res Commun, vol. 343, no. 4, May 2006, pp. 1060–66. Pubmed, doi:10.1016/j.bbrc.2006.03.065.
Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman HA. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun. 2006 May 19;343(4):1060–1066.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

May 19, 2006

Volume

343

Issue

4

Start / End Page

1060 / 1066

Location

United States

Related Subject Headings

  • Phenotype
  • Myocardium
  • Mitogen-Activated Protein Kinase 9
  • Mitogen-Activated Protein Kinase 8
  • Mitogen-Activated Protein Kinase 10
  • Mice, Knockout
  • Mice
  • Male
  • In Situ Nick-End Labeling
  • Female