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Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs.

Publication ,  Journal Article
Kambayashi, M; Miura, T; Oh, BH; Murata, K; Rockman, HA; Parra, G; Ross, J
Published in: Circulation
December 1992

BACKGROUND: The potential role of myocardial cell hypertrophy in the ischemic zone in the mechanism of late recovery of regional contractile function after myocardial infarction followed by reperfusion has not been examined. METHODS AND RESULTS: Eight chronically instrumented, conscious dogs were subjected to 90-120 minutes of circumflex coronary artery occlusion followed by reperfusion. The thickness and function of the anterior (AT) and posterior (PT) walls was measured by ultrasonic gauges at control, during occlusion, and after reperfusion. After 3 weeks, cross-sectional areas of surviving cells were determined from subepicardial (epi), midwall (mid), and subendocardial (endo) regions in six dogs and compared with those from six animals without infarction, including three sham-operated control dogs. PT systolic wall thickening showed dyskinesia during occlusion but recovered after reperfusion to 48% of control at 1 week and 67% at 3 weeks. End-diastolic thickness of the PT wall increased markedly after reperfusion, but AT and PT walls were only slightly thicker (p = NS) than in control dogs at 3 weeks. Cross-sectional areas of reperfused dogs in the infarct region averaged 279 (PTepi), 291 (PTmid), and 317 microns 2 (PTendo) and were significantly larger than in control animals (237 [PTepi], 241 [PTmid], and 233 microns 2 [PTendo]). PT cell areas were significantly larger than AT cells, ENDO cell areas were larger than EPI cells (both p < 0.05), and ENDO cells of the AT wall were larger than those of noninfarcted dogs (p < 0.05). CONCLUSIONS: In dogs with myocardial infarction followed by reperfusion, the cross-sectional areas of cells in the infarcted PT wall were larger than those in the noninfarcted AT wall, and within both the infarcted and noninfarcted zones, cell areas were larger in the endocardial than the epicardial region. In all regions of the infarcted wall and in the ENDO region of the noninfarcted wall, cell areas were generally larger than those of control dogs without infarction, and the control dogs showed no transmural differences in cell areas. The mechanisms responsible for this significant remodeling of the reperfused infarcted zone, which involves myocardial cellular hypertrophy, are unknown, but it is possible that hypertrophy of surviving regions of the infarcted wall played a role in the late recovery of regional function that accompanied this hypertrophic response.

Duke Scholars

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

December 1992

Volume

86

Issue

6

Start / End Page

1935 / 1944

Location

United States

Related Subject Headings

  • Systole
  • Myocardium
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Male
  • Hemodynamics
  • Heart
  • Female
  • Dogs
  • Diastole
 

Citation

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Kambayashi, M., Miura, T., Oh, B. H., Murata, K., Rockman, H. A., Parra, G., & Ross, J. (1992). Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs. Circulation, 86(6), 1935–1944. https://doi.org/10.1161/01.cir.86.6.1935
Kambayashi, M., T. Miura, B. H. Oh, K. Murata, H. A. Rockman, G. Parra, and J. Ross. “Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs.Circulation 86, no. 6 (December 1992): 1935–44. https://doi.org/10.1161/01.cir.86.6.1935.
Kambayashi M, Miura T, Oh BH, Murata K, Rockman HA, Parra G, et al. Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs. Circulation. 1992 Dec;86(6):1935–44.
Kambayashi, M., et al. “Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs.Circulation, vol. 86, no. 6, Dec. 1992, pp. 1935–44. Pubmed, doi:10.1161/01.cir.86.6.1935.
Kambayashi M, Miura T, Oh BH, Murata K, Rockman HA, Parra G, Ross J. Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs. Circulation. 1992 Dec;86(6):1935–1944.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

December 1992

Volume

86

Issue

6

Start / End Page

1935 / 1944

Location

United States

Related Subject Headings

  • Systole
  • Myocardium
  • Myocardial Reperfusion
  • Myocardial Infarction
  • Male
  • Hemodynamics
  • Heart
  • Female
  • Dogs
  • Diastole