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Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes.

Publication ,  Journal Article
Brauer, LH; Cramblett, MJ; Paxton, DA; Rose, JE
Published in: Psychopharmacology (Berl)
December 2001

RATIONALE: Studies with laboratory animals and humans suggest that dopamine may play a role in maintaining cigarette smoking behavior via its interactions with nicotine. OBJECTIVES: This study was designed to replicate and extend previous findings showing that the dopamine D2 antagonist, haloperidol, produces blockade of smoking reward and compensatory increases in smoking. METHODS: We studied 20 subjects in a 2x3 within-subjects design, with nicotine-containing or denicotinized cigarettes crossed with oral placebo, haloperidol 1 mg, or haloperidol 2 mg. Subjects attended six sessions during which they received one of the cigarette/drug combinations, and smoked under both controlled and ad libitum conditions. Cigarette and mood ratings and smoking behavior were assessed. RESULTS: Haloperidol reduced the number of cigarettes smoked and the carbon monoxide boost associated with both types of cigarettes, at doses that did not appear to produce clinically significant behavioral effects. CONCLUSIONS: Dopamine appears to play a role in mediating smoking behavior, but this may occur through a non-nicotine mechanism.

Duke Scholars

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

December 2001

Volume

159

Issue

1

Start / End Page

31 / 37

Location

Germany

Related Subject Headings

  • Smoking
  • Psychiatry
  • Nicotinic Agonists
  • Nicotine
  • Male
  • Humans
  • Haloperidol
  • Female
  • Double-Blind Method
  • Dopamine Antagonists
 

Citation

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Brauer, L. H., Cramblett, M. J., Paxton, D. A., & Rose, J. E. (2001). Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. Psychopharmacology (Berl), 159(1), 31–37. https://doi.org/10.1007/s002130100894
Brauer, L. H., M. J. Cramblett, D. A. Paxton, and J. E. Rose. “Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes.Psychopharmacology (Berl) 159, no. 1 (December 2001): 31–37. https://doi.org/10.1007/s002130100894.
Brauer LH, Cramblett MJ, Paxton DA, Rose JE. Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. Psychopharmacology (Berl). 2001 Dec;159(1):31–7.
Brauer, L. H., et al. “Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes.Psychopharmacology (Berl), vol. 159, no. 1, Dec. 2001, pp. 31–37. Pubmed, doi:10.1007/s002130100894.
Brauer LH, Cramblett MJ, Paxton DA, Rose JE. Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. Psychopharmacology (Berl). 2001 Dec;159(1):31–37.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

ISSN

0033-3158

Publication Date

December 2001

Volume

159

Issue

1

Start / End Page

31 / 37

Location

Germany

Related Subject Headings

  • Smoking
  • Psychiatry
  • Nicotinic Agonists
  • Nicotine
  • Male
  • Humans
  • Haloperidol
  • Female
  • Double-Blind Method
  • Dopamine Antagonists