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Transdermal administration of nicotine.

Publication ,  Journal Article
Rose, JE; Jarvik, ME; Rose, KD
Published in: Drug Alcohol Depend
May 1984

The physiological response to nicotine topically applied to the skin was measured in an adult male volunteer. Nicotine base (9 mg) was applied in a 30% aqueous solution to intact skin on the underside of the forearm. Salivary nicotine, heart rate and blood pressure were monitored for 12 h after application of the nicotine. Within 30 min a significant level of nicotine was detected in the saliva (50 ng/ml), pulse had risen by 15 beats/min and systolic blood pressure had risen 10 mmHg. Nicotine levels remained elevated for 2 h and were comparable to levels of nicotine produced by cigarette smoking. Because previous research has shown nicotine to suppress smoking behavior, it may be fruitful to examine transdermal administration of nicotine as a smoking reduction and cessation aid.

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Published In

Drug Alcohol Depend

DOI

ISSN

0376-8716

Publication Date

May 1984

Volume

13

Issue

3

Start / End Page

209 / 213

Location

Ireland

Related Subject Headings

  • Substance Abuse
  • Skin Absorption
  • Saliva
  • Nicotine
  • Male
  • Humans
  • Heart Rate
  • Blood Pressure
  • Adult
  • Administration, Topical
 

Citation

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Rose, J. E., Jarvik, M. E., & Rose, K. D. (1984). Transdermal administration of nicotine. Drug Alcohol Depend, 13(3), 209–213. https://doi.org/10.1016/0376-8716(84)90061-9
Rose, J. E., M. E. Jarvik, and K. D. Rose. “Transdermal administration of nicotine.Drug Alcohol Depend 13, no. 3 (May 1984): 209–13. https://doi.org/10.1016/0376-8716(84)90061-9.
Rose JE, Jarvik ME, Rose KD. Transdermal administration of nicotine. Drug Alcohol Depend. 1984 May;13(3):209–13.
Rose, J. E., et al. “Transdermal administration of nicotine.Drug Alcohol Depend, vol. 13, no. 3, May 1984, pp. 209–13. Pubmed, doi:10.1016/0376-8716(84)90061-9.
Rose JE, Jarvik ME, Rose KD. Transdermal administration of nicotine. Drug Alcohol Depend. 1984 May;13(3):209–213.
Journal cover image

Published In

Drug Alcohol Depend

DOI

ISSN

0376-8716

Publication Date

May 1984

Volume

13

Issue

3

Start / End Page

209 / 213

Location

Ireland

Related Subject Headings

  • Substance Abuse
  • Skin Absorption
  • Saliva
  • Nicotine
  • Male
  • Humans
  • Heart Rate
  • Blood Pressure
  • Adult
  • Administration, Topical