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Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.

Publication ,  Journal Article
Yanai, J; Rogel-Fuchs, Y; Pick, CG; Slotkin, T; Seidler, FJ; Zahalka, EA; Newman, ME
Published in: Neuropharmacology
February 1993

Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation of the postsynaptic receptors. Levels of dopamine in the septum were reduced by 70% in the lesioned animals and hippocampal choline acetyltransferase was elevated by the same amount. The Bmax of muscarinic binding was significantly reduced without changes in Kd; nevertheless, carbachol-induced stimulation of formation of inositol phosphate was unaffected. The response to K+ was markedly elevated in the 6-hydroxydopamine-treated animals. Thus, the regulatory effect of A10-septal dopaminergic pathways on the septohippocampal cholinergic innervations is both on the presynaptic and postsynaptic levels.

Duke Scholars

Published In

Neuropharmacology

DOI

ISSN

0028-3908

Publication Date

February 1993

Volume

32

Issue

2

Start / End Page

113 / 117

Location

England

Related Subject Headings

  • Sympathectomy, Chemical
  • Receptors, Muscarinic
  • Potassium
  • Parasympathetic Nervous System
  • Oxidopamine
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mice
  • Male
  • Inositol Phosphates
 

Citation

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Chicago
ICMJE
MLA
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Yanai, J., Rogel-Fuchs, Y., Pick, C. G., Slotkin, T., Seidler, F. J., Zahalka, E. A., & Newman, M. E. (1993). Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. Neuropharmacology, 32(2), 113–117. https://doi.org/10.1016/0028-3908(93)90090-p
Yanai, J., Y. Rogel-Fuchs, C. G. Pick, T. Slotkin, F. J. Seidler, E. A. Zahalka, and M. E. Newman. “Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.Neuropharmacology 32, no. 2 (February 1993): 113–17. https://doi.org/10.1016/0028-3908(93)90090-p.
Yanai J, Rogel-Fuchs Y, Pick CG, Slotkin T, Seidler FJ, Zahalka EA, et al. Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. Neuropharmacology. 1993 Feb;32(2):113–7.
Yanai, J., et al. “Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.Neuropharmacology, vol. 32, no. 2, Feb. 1993, pp. 113–17. Pubmed, doi:10.1016/0028-3908(93)90090-p.
Yanai J, Rogel-Fuchs Y, Pick CG, Slotkin T, Seidler FJ, Zahalka EA, Newman ME. Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. Neuropharmacology. 1993 Feb;32(2):113–117.
Journal cover image

Published In

Neuropharmacology

DOI

ISSN

0028-3908

Publication Date

February 1993

Volume

32

Issue

2

Start / End Page

113 / 117

Location

England

Related Subject Headings

  • Sympathectomy, Chemical
  • Receptors, Muscarinic
  • Potassium
  • Parasympathetic Nervous System
  • Oxidopamine
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mice
  • Male
  • Inositol Phosphates