Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy.

Publication ,  Journal Article
Shlyonsky, VG; Markin, VS; Andreeva, I; Pedersen, SE; Simon, SA; Benos, DJ; Ismailov, II
Published in: Biochim Biophys Acta
November 2006

We describe the phenomenon of mechanoelectrical transduction in macroscopic lipid bilayer membranes modified by two cation-selective ionophores, valinomycin and nonactin. We found that bulging these membranes, while maintaining the membrane tension constant, produced a marked supralinear increase in specific carrier-mediated conductance. Analyses of the mechanisms involved in mechanoelectrical transduction induced by the imposition of a hydrostatic pressure gradient or by an amphipathic compound chlorpromazine reveal similar changes in the charge carrier motility and carrier reaction rates at the interface(s). Furthermore, the relative change in membrane conductance was independent of membrane diameter, but was directly proportional to the square of membrane curvature, thus relating the observed phenomena to the bilayer bending energy. Extrapolated to biological membranes, these findings indicate that ion transport in cells can be influenced simply by changing shape of the membrane, without a change in membrane tension.

Duke Scholars

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

November 2006

Volume

1758

Issue

11

Start / End Page

1723 / 1731

Location

Netherlands

Related Subject Headings

  • Valinomycin
  • Thermodynamics
  • Models, Biological
  • Membrane Potentials
  • Mathematics
  • Macrolides
  • Lipid Bilayers
  • Kinetics
  • Iontophoresis
  • Hydrostatic Pressure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shlyonsky, V. G., Markin, V. S., Andreeva, I., Pedersen, S. E., Simon, S. A., Benos, D. J., & Ismailov, I. I. (2006). Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. Biochim Biophys Acta, 1758(11), 1723–1731. https://doi.org/10.1016/j.bbamem.2006.09.016
Shlyonsky, V Gh, V. S. Markin, I. Andreeva, S. E. Pedersen, S. A. Simon, D. J. Benos, and I. I. Ismailov. “Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy.Biochim Biophys Acta 1758, no. 11 (November 2006): 1723–31. https://doi.org/10.1016/j.bbamem.2006.09.016.
Shlyonsky VG, Markin VS, Andreeva I, Pedersen SE, Simon SA, Benos DJ, et al. Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. Biochim Biophys Acta. 2006 Nov;1758(11):1723–31.
Shlyonsky, V. Gh, et al. “Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy.Biochim Biophys Acta, vol. 1758, no. 11, Nov. 2006, pp. 1723–31. Pubmed, doi:10.1016/j.bbamem.2006.09.016.
Shlyonsky VG, Markin VS, Andreeva I, Pedersen SE, Simon SA, Benos DJ, Ismailov II. Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. Biochim Biophys Acta. 2006 Nov;1758(11):1723–1731.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

November 2006

Volume

1758

Issue

11

Start / End Page

1723 / 1731

Location

Netherlands

Related Subject Headings

  • Valinomycin
  • Thermodynamics
  • Models, Biological
  • Membrane Potentials
  • Mathematics
  • Macrolides
  • Lipid Bilayers
  • Kinetics
  • Iontophoresis
  • Hydrostatic Pressure