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A simple model for calcium induced exocytosis.

Publication ,  Journal Article
Hall, JE; Simon, SA
Published in: Biochim Biophys Acta
July 1, 1976
Published version (DOI) Link to item

We have developed a simple model showing how the presence or obsence of Ca2+ can determine whether an uncurved or curved membrane surface is favored energetically. The model shows why fusion of vesicles with the presynaptic membrane is favored in the presence of calcium and why the budding off of vesicles is favored in the absence of calcium inside of the presynaptic membrane. The model accurately predicts the radius of a synaptic vesicle using known properties of lipids and suggests consequences of temperature change, varied stimulation rate and addition of calcium by artificial means on rates of transmitter release.

Duke Scholars

Sidney Arthur Simon
Author Sidney Arthur Simon Neurobiology

Published In

Biochim Biophys Acta

DOI

10.1016/0005-2736(76)90444-2

ISSN

0006-3002

Publication Date

July 1, 1976

Volume

436

Issue

3

Start / End Page

613 / 616

Location

Netherlands

Related Subject Headings

  • Models, Biological
  • Membranes, Artificial
  • Mathematics
  • Exocytosis
  • Calcium
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences
 

Citation

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Hall, J. E., & Simon, S. A. (1976). A simple model for calcium induced exocytosis. Biochim Biophys Acta, 436(3), 613–616. https://doi.org/10.1016/0005-2736(76)90444-2
Hall, J. E., and S. A. Simon. “A simple model for calcium induced exocytosis.” Biochim Biophys Acta 436, no. 3 (July 1, 1976): 613–16. https://doi.org/10.1016/0005-2736(76)90444-2.
Hall JE, Simon SA. A simple model for calcium induced exocytosis. Biochim Biophys Acta. 1976 Jul 1;436(3):613–6.
Hall, J. E., and S. A. Simon. “A simple model for calcium induced exocytosis.” Biochim Biophys Acta, vol. 436, no. 3, July 1976, pp. 613–16. Pubmed, doi:10.1016/0005-2736(76)90444-2.
Hall JE, Simon SA. A simple model for calcium induced exocytosis. Biochim Biophys Acta. 1976 Jul 1;436(3):613–616.

Published In

Biochim Biophys Acta

DOI

10.1016/0005-2736(76)90444-2

ISSN

0006-3002

Publication Date

July 1, 1976

Volume

436

Issue

3

Start / End Page

613 / 616

Location

Netherlands

Related Subject Headings

  • Models, Biological
  • Membranes, Artificial
  • Mathematics
  • Exocytosis
  • Calcium
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
  • 02 Physical Sciences