Nmr investigation of a microtubule binding region peptide from human tau (τ) protein
Publication
, Journal Article
De Serrano, V; Ribeiro, AA; Strittmatter, WJ; Spicer, LD
Published in: Protein and Peptide Letters
December 1, 1997
Solution NMR studies of τD1, an 18-residue microtubule binding peptide from domain 1 of human tau protein, are reported. Using 2D 1H NMR (TOCSY, NOESY and ROESY) at 5 and 37°C, we assigned the resonances of almost all protons of τD1 at pH 4.2,5.8 and 7.3. While overall the peptide is highly disordered, several medium range NOE's give evidence for conformational preferences involving a bend at the T8-Q14 segment of the peptide.
Duke Scholars
Published In
Protein and Peptide Letters
ISSN
0929-8665
Publication Date
December 1, 1997
Volume
4
Issue
3
Start / End Page
165 / 172
Related Subject Headings
- Biophysics
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry
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MLA
NLM
De Serrano, V., Ribeiro, A. A., Strittmatter, W. J., & Spicer, L. D. (1997). Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters, 4(3), 165–172.
De Serrano, V., A. A. Ribeiro, W. J. Strittmatter, and L. D. Spicer. “Nmr investigation of a microtubule binding region peptide from human tau (τ) protein.” Protein and Peptide Letters 4, no. 3 (December 1, 1997): 165–72.
De Serrano V, Ribeiro AA, Strittmatter WJ, Spicer LD. Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters. 1997 Dec 1;4(3):165–72.
De Serrano, V., et al. “Nmr investigation of a microtubule binding region peptide from human tau (τ) protein.” Protein and Peptide Letters, vol. 4, no. 3, Dec. 1997, pp. 165–72.
De Serrano V, Ribeiro AA, Strittmatter WJ, Spicer LD. Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters. 1997 Dec 1;4(3):165–172.
Published In
Protein and Peptide Letters
ISSN
0929-8665
Publication Date
December 1, 1997
Volume
4
Issue
3
Start / End Page
165 / 172
Related Subject Headings
- Biophysics
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry