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Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.

Publication ,  Journal Article
Patisaul, HB; Roberts, SC; Mabrey, N; McCaffrey, KA; Gear, RB; Braun, J; Belcher, SM; Stapleton, HM
Published in: Journal of biochemical and molecular toxicology
February 2013

Firemaster® 550 (FM 550), a fire-retardant mixture used in foam-based products, was recently identified as a common contaminant in household dust. The chemical structures of its principle components suggest they have endocrine disrupting activity, but nothing is known about their physiological effects at environmentally relevant exposure levels. The goal of this exploratory study was to evaluate accumulation, metabolism and endocrine disrupting effects of FM 550 in rats exposed to 100 or 1000 µg/day across gestation and lactation. FM 550 components accumulated in tissues of exposed dams and offspring and induced phenotypic hallmarks associated with metabolic syndrome in the offspring. Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring. Results of this study are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels.

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Published In

Journal of biochemical and molecular toxicology

DOI

EISSN

1099-0461

ISSN

1095-6670

Publication Date

February 2013

Volume

27

Issue

2

Start / End Page

124 / 136

Related Subject Headings

  • Toxicology
  • Thyroxine
  • Rats, Wistar
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obesity
  • Maternal Exposure
  • Male
  • Flame Retardants
 

Citation

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Patisaul, H. B., Roberts, S. C., Mabrey, N., McCaffrey, K. A., Gear, R. B., Braun, J., … Stapleton, H. M. (2013). Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. Journal of Biochemical and Molecular Toxicology, 27(2), 124–136. https://doi.org/10.1002/jbt.21439
Patisaul, Heather B., Simon C. Roberts, Natalie Mabrey, Katherine A. McCaffrey, Robin B. Gear, Joe Braun, Scott M. Belcher, and Heather M. Stapleton. “Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.Journal of Biochemical and Molecular Toxicology 27, no. 2 (February 2013): 124–36. https://doi.org/10.1002/jbt.21439.
Patisaul HB, Roberts SC, Mabrey N, McCaffrey KA, Gear RB, Braun J, et al. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. Journal of biochemical and molecular toxicology. 2013 Feb;27(2):124–36.
Patisaul, Heather B., et al. “Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.Journal of Biochemical and Molecular Toxicology, vol. 27, no. 2, Feb. 2013, pp. 124–36. Epmc, doi:10.1002/jbt.21439.
Patisaul HB, Roberts SC, Mabrey N, McCaffrey KA, Gear RB, Braun J, Belcher SM, Stapleton HM. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. Journal of biochemical and molecular toxicology. 2013 Feb;27(2):124–136.
Journal cover image

Published In

Journal of biochemical and molecular toxicology

DOI

EISSN

1099-0461

ISSN

1095-6670

Publication Date

February 2013

Volume

27

Issue

2

Start / End Page

124 / 136

Related Subject Headings

  • Toxicology
  • Thyroxine
  • Rats, Wistar
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obesity
  • Maternal Exposure
  • Male
  • Flame Retardants