Scholars@Duke publication: Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers

Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers

Publication , Journal Article

Li, G; Ghoroghchian, P; Qi, W; Christian, N; Frail, PR; Hammer, DA; Therien, MJ

Published in: Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

October 1, 2008

A series of amphiphilic poly(ethylene oxide)-b-polycaprolactone (PEO-b-PCL) diblock copolymers had been synthesized by ring-opening or sequential anionic living polymerization. Nuclear Magnetic Resonance (NMR) and gel permeation chromatography (GPC) were used to characterize these copolymers. All copolymers have polydispersity index (PDI) from 1.14 to 1.37 by GPC. Two self-assembly techniques, film rehydration and organic solvent extraction, had been employed to process polymersomes. The perfect nanostructured polymersomes were processed by freeze-thaw-sonication film rehydration technique. The polymersomes with sizes from a hundred nanometer to several microns were obtained from these copolymers. Polymersomes could only be made from the copolymers with PEO blocks (Mn: 2k-3.8k) and fPEO (11.8-18.8%). Film rehydration is a highly favorable self-assembly method for preparing biodegradable nanostructured polymersomes.

Duke Scholars

Author Michael J. Therien Chemistry

Published In

Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

Publication Date

October 1, 2008

Volume

Start / End Page

661 / 664

Citation

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Li, G., Ghoroghchian, P., Qi, W., Christian, N., Frail, P. R., Hammer, D. A., & Therien, M. J. (2008). Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, 2, 661–664.

Li, G., P. Ghoroghchian, W. Qi, N. Christian, P. R. Frail, D. A. Hammer, and M. J. Therien. “Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers.” Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 2 (October 1, 2008): 661–64.

Li G, Ghoroghchian P, Qi W, Christian N, Frail PR, Hammer DA, et al. Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008 Oct 1;2:661–4.

Li, G., et al. “Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers.” Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, vol. 2, Oct. 2008, pp. 661–64.

Li G, Ghoroghchian P, Qi W, Christian N, Frail PR, Hammer DA, Therien MJ. Synthesis and self-assembly of biodegradable polyethylene oxide-b-polycaprolactone (PEO-A-PCL) diblock copolymers. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008 Oct 1;2:661–664.

Published In

Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008