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Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device.

Publication ,  Journal Article
Selgrade, BP; Truskey, GA
Published in: Artificial organs
April 2012

Axial flow left ventricular assist devices (LVADs) are a significant improvement in mechanical circulatory support. However, patients with these devices experience degradation of large von Willebrand factor (vWF) multimers, which is associated with bleeding and may be caused by high shear stresses within the LVAD. In this study, we used computational fluid mechanics to determine the wall shear stresses, shear rates, and residence times in a centrifugal LVAD and assess the impact on these variables caused by changing impeller speed and changing from a shrouded to a semi-open impeller. In both LVAD types, shear rates were well over 10,000/s in several regions. This is high enough to degrade vWF, but it is unclear if residence times, which were below 5ms in high-shear regions, are long enough to allow vWF cleavage. Additionally, wall shear stresses were below the threshold stress of 10Pa only in the outlet tube so it is feasible to endothelialize this region to enhance its biocompatibility.

Duke Scholars

Published In

Artificial organs

DOI

EISSN

1525-1594

ISSN

0160-564X

Publication Date

April 2012

Volume

36

Issue

4

Start / End Page

E89 / E96

Related Subject Headings

  • von Willebrand Factor
  • Ventricular Function
  • Stress, Mechanical
  • Hydrodynamics
  • Humans
  • Hemodynamics
  • Heart-Assist Devices
  • Equipment Design
  • Biomedical Engineering
  • 4003 Biomedical engineering
 

Citation

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Selgrade, B. P., & Truskey, G. A. (2012). Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device. Artificial Organs, 36(4), E89–E96. https://doi.org/10.1111/j.1525-1594.2011.01416.x
Selgrade, Brian Paul, and George A. Truskey. “Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device.Artificial Organs 36, no. 4 (April 2012): E89–96. https://doi.org/10.1111/j.1525-1594.2011.01416.x.
Selgrade, Brian Paul, and George A. Truskey. “Computational fluid dynamics analysis to determine shear stresses and rates in a centrifugal left ventricular assist device.Artificial Organs, vol. 36, no. 4, Apr. 2012, pp. E89–96. Epmc, doi:10.1111/j.1525-1594.2011.01416.x.
Journal cover image

Published In

Artificial organs

DOI

EISSN

1525-1594

ISSN

0160-564X

Publication Date

April 2012

Volume

36

Issue

4

Start / End Page

E89 / E96

Related Subject Headings

  • von Willebrand Factor
  • Ventricular Function
  • Stress, Mechanical
  • Hydrodynamics
  • Humans
  • Hemodynamics
  • Heart-Assist Devices
  • Equipment Design
  • Biomedical Engineering
  • 4003 Biomedical engineering