Mechanism of shear force-dependent monocyte adhesion to vascular endothelium
Publication
, Journal Article
Rinker, KD; Ting-Beall, HP; Hochmuth, RM; Truskey, GA
Published in: Annals of Biomedical Engineering
December 1, 2000
As fluid shear stress and hence net force on cells increases at a constant shear rate (contact time), monocyte adhesion increases. This phenomena is hypothesized to result from penetration of charge barriers and increased deformation of the monocytic cell line Mono Mac 6. It is show that at higher shear forces, the greater cell deformation of the linoleic acid modified cells compensates for the increase in shear rate to a greater extent than the control cells. Since monocyte membrane linoleic acid content increases upon incubation with LDL, these results suggest that changes in the mechanical behavior of monocytes may occur during atherosclerosis promoting further monocyte adhesion to endothelium.
Duke Scholars
Published In
Annals of Biomedical Engineering
ISSN
0090-6964
Publication Date
December 1, 2000
Volume
28
Issue
SUPPL. 1
Related Subject Headings
- Biomedical Engineering
- 11 Medical and Health Sciences
- 09 Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Rinker, K. D., Ting-Beall, H. P., Hochmuth, R. M., & Truskey, G. A. (2000). Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering, 28(SUPPL. 1).
Rinker, K. D., H. P. Ting-Beall, R. M. Hochmuth, and G. A. Truskey. “Mechanism of shear force-dependent monocyte adhesion to vascular endothelium.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
Rinker KD, Ting-Beall HP, Hochmuth RM, Truskey GA. Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Rinker, K. D., et al. “Mechanism of shear force-dependent monocyte adhesion to vascular endothelium.” Annals of Biomedical Engineering, vol. 28, no. SUPPL. 1, Dec. 2000.
Rinker KD, Ting-Beall HP, Hochmuth RM, Truskey GA. Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Published In
Annals of Biomedical Engineering
ISSN
0090-6964
Publication Date
December 1, 2000
Volume
28
Issue
SUPPL. 1
Related Subject Headings
- Biomedical Engineering
- 11 Medical and Health Sciences
- 09 Engineering