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Mechanism of shear force-dependent monocyte adhesion to vascular endothelium

Publication ,  Journal Article
Rinker, KD; Ting-Beall, HP; Hochmuth, RM; Truskey, GA
Published in: Annals of Biomedical Engineering
December 1, 2000

As fluid shear stress and hence net force on cells increases at a constant shear rate (contact time), monocyte adhesion increases. This phenomena is hypothesized to result from penetration of charge barriers and increased deformation of the monocytic cell line Mono Mac 6. It is show that at higher shear forces, the greater cell deformation of the linoleic acid modified cells compensates for the increase in shear rate to a greater extent than the control cells. Since monocyte membrane linoleic acid content increases upon incubation with LDL, these results suggest that changes in the mechanical behavior of monocytes may occur during atherosclerosis promoting further monocyte adhesion to endothelium.

Duke Scholars

Published In

Annals of Biomedical Engineering

ISSN

0090-6964

Publication Date

December 1, 2000

Volume

28

Issue

SUPPL. 1

Related Subject Headings

  • Biomedical Engineering
  • 11 Medical and Health Sciences
  • 09 Engineering
 

Citation

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Rinker, K. D., Ting-Beall, H. P., Hochmuth, R. M., & Truskey, G. A. (2000). Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering, 28(SUPPL. 1).
Rinker, K. D., H. P. Ting-Beall, R. M. Hochmuth, and G. A. Truskey. “Mechanism of shear force-dependent monocyte adhesion to vascular endothelium.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
Rinker KD, Ting-Beall HP, Hochmuth RM, Truskey GA. Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Rinker, K. D., et al. “Mechanism of shear force-dependent monocyte adhesion to vascular endothelium.” Annals of Biomedical Engineering, vol. 28, no. SUPPL. 1, Dec. 2000.
Rinker KD, Ting-Beall HP, Hochmuth RM, Truskey GA. Mechanism of shear force-dependent monocyte adhesion to vascular endothelium. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Journal cover image

Published In

Annals of Biomedical Engineering

ISSN

0090-6964

Publication Date

December 1, 2000

Volume

28

Issue

SUPPL. 1

Related Subject Headings

  • Biomedical Engineering
  • 11 Medical and Health Sciences
  • 09 Engineering