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Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms.

Publication ,  Journal Article
Turaga, KK; Beasley, GM; Kane, JM; Delman, KA; Grobmyer, SR; Gonzalez, RJ; Letson, GD; Cheong, D; Tyler, DS; Zager, JS
Published in: Arch Surg
July 2011

OBJECTIVE: To demonstrate the efficacy of isolated limb infusion (ILI) in limb preservation for patients with locally advanced soft-tissue sarcomas and nonmelanoma cutaneous malignant neoplasms. BACKGROUND: Locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms, including soft-tissue sarcomas of the extremities, can pose significant treatment challenges. We report our experience, including responses and limb preservation rates, using ILI in cutaneous and soft-tissue malignant neoplasms. METHODS: We identified 22 patients with cutaneous and soft-tissue malignant neoplasms who underwent 26 ILIs with melphalan and dactinomycin from January 1, 2004, through December 31, 2009, from 5 institutions. Outcome measures included limb preservation and in-field response rates. Regional toxic effects were measured using the Wieberdink scale and serum creatinine phosphokinase levels. RESULTS: The median age was 70 years (range, 19-92 years), and 12 patients (55%) were women. Fourteen patients (64%) had sarcomas, 7 (32%) had Merkel cell carcinoma, and 1 (5%) had squamous cell carcinoma. The median length of stay was 5.5 days (interquartile range, 4-8 days). Twenty-five of the 26 ILIs (96%) resulted in Wieberdink grade III or less toxicity, and 1 patient (4%) developed grade IV toxicity. The median serum creatinine phosphokinase level was 127 U/L for upper extremity ILIs and 93 U/L for lower extremity ILIs. Nineteen of 22 patients (86%) underwent successful limb preservation. The 3-month in-field response rate was 79% (21% complete and 58% partial), and the median follow-up was 8.6 months (range, 1-63 months). Five patients underwent resection of disease after an ILI, of whom 80% are disease free at a median of 8.6 months. CONCLUSIONS: Isolated limb infusion provides an attractive alternative therapy for regional disease control and limb preservation in patients with limb-threatening cutaneous and soft-tissue malignant neoplasms. Short-term response rates appear encouraging, yet durability of response is unknown.

Duke Scholars

Published In

Arch Surg

DOI

EISSN

1538-3644

Publication Date

July 2011

Volume

146

Issue

7

Start / End Page

870 / 875

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Surgery
  • Soft Tissue Neoplasms
  • Skin Neoplasms
  • Sarcoma
  • Retrospective Studies
  • Middle Aged
  • Melphalan
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Turaga, K. K., Beasley, G. M., Kane, J. M., Delman, K. A., Grobmyer, S. R., Gonzalez, R. J., … Zager, J. S. (2011). Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg, 146(7), 870–875. https://doi.org/10.1001/archsurg.2011.139
Turaga, Kiran K., Georgia M. Beasley, John M. Kane, Keith A. Delman, Stephen R. Grobmyer, Ricardo J. Gonzalez, G Douglas Letson, David Cheong, Douglas S. Tyler, and Jonathan S. Zager. “Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms.Arch Surg 146, no. 7 (July 2011): 870–75. https://doi.org/10.1001/archsurg.2011.139.
Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, et al. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul;146(7):870–5.
Turaga, Kiran K., et al. “Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms.Arch Surg, vol. 146, no. 7, July 2011, pp. 870–75. Pubmed, doi:10.1001/archsurg.2011.139.
Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, Letson GD, Cheong D, Tyler DS, Zager JS. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul;146(7):870–875.

Published In

Arch Surg

DOI

EISSN

1538-3644

Publication Date

July 2011

Volume

146

Issue

7

Start / End Page

870 / 875

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Surgery
  • Soft Tissue Neoplasms
  • Skin Neoplasms
  • Sarcoma
  • Retrospective Studies
  • Middle Aged
  • Melphalan
  • Male