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Evolution of the segregation ratio: modification of gene conversion and meiotic drive.

Publication ,  Journal Article
Bengtsson, BO; Uyenoyama, MK
Published in: Theoretical population biology
October 1990

We compare the evolutionary pressures that direct the modification of gene conversion and meiotic drive at loci subject to purifying and overdominant viability selection. Gene conversion differs from meiotic drive in that modifers do not affect their own segregation ratios, even when linked to the viability locus. Segregation distortion generates gametic level disequilibria between alleles at the viability locus and modifiers of gene conversion and meiotic drive: enhancers of segregation distortion become positively associated with driven alleles. Suppression of gene conversion evolves if the driven allele is marginally disadvantageous (overdominant viability selection), and higher rates evolve if the driven alleles are relatively advantageous (purifying viability selection). Gametic disequilibria permit enhancers of meiotic drive that are linked to the driven locus to promote their own segregation. We attribute the failure of genetic modifiers of gene conversion and meiotic drive to maximinize mean fitness to the generation of such associations.

Duke Scholars

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

October 1990

Volume

38

Issue

2

Start / End Page

192 / 218

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Meiosis
  • Humans
  • Genetics, Population
  • Genetic Linkage
  • Gene Conversion
  • Evolutionary Biology
  • Biological Evolution
  • 4901 Applied mathematics
 

Citation

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Bengtsson, B. O., & Uyenoyama, M. K. (1990). Evolution of the segregation ratio: modification of gene conversion and meiotic drive. Theoretical Population Biology, 38(2), 192–218. https://doi.org/10.1016/0040-5809(90)90010-s
Bengtsson, B. O., and M. K. Uyenoyama. “Evolution of the segregation ratio: modification of gene conversion and meiotic drive.Theoretical Population Biology 38, no. 2 (October 1990): 192–218. https://doi.org/10.1016/0040-5809(90)90010-s.
Bengtsson BO, Uyenoyama MK. Evolution of the segregation ratio: modification of gene conversion and meiotic drive. Theoretical population biology. 1990 Oct;38(2):192–218.
Bengtsson, B. O., and M. K. Uyenoyama. “Evolution of the segregation ratio: modification of gene conversion and meiotic drive.Theoretical Population Biology, vol. 38, no. 2, Oct. 1990, pp. 192–218. Epmc, doi:10.1016/0040-5809(90)90010-s.
Bengtsson BO, Uyenoyama MK. Evolution of the segregation ratio: modification of gene conversion and meiotic drive. Theoretical population biology. 1990 Oct;38(2):192–218.
Journal cover image

Published In

Theoretical population biology

DOI

EISSN

1096-0325

ISSN

0040-5809

Publication Date

October 1990

Volume

38

Issue

2

Start / End Page

192 / 218

Related Subject Headings

  • Selection, Genetic
  • Mutation
  • Meiosis
  • Humans
  • Genetics, Population
  • Genetic Linkage
  • Gene Conversion
  • Evolutionary Biology
  • Biological Evolution
  • 4901 Applied mathematics