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[Expression of presenilin 1 on the cell surface in motile polarized cells].

Publication ,  Journal Article
Shvartsman, AL; Sarantseva, SV; Tatishcheva, IA; Runova, OL; Talalaeva, EI; Vitek, MP
Published in: Biofizika
2006

Most cases of familial early-onset Alzheimer's disease are caused by mutations in the presenilin 1 (PS1) gene. However, the cellular functions of PS1 are not yet completely understood. We showed that endogenous PS1 and the adhesion protein CD44 are redistributed on the surface of cell projections (lamellipodia) in polarized T- lymphocytes (Jurkat cells) after the adhesion to a collagen matrix. This effect was not observed for another surface protein of T lymphocytes, which is not involved in cell adhesion processes, the T cell receptor. In primary cultures of mouse cortical neurons, PS1 was concentrated at the surface of extended growth cones and at the sites of neurite contacts. The concentration of PS1 at the surface of cellular structures that promote cell motility and cell contacts suggests an important role of PSI in cell adhesion in motile polarized cells.

Duke Scholars

Published In

Biofizika

ISSN

0006-3029

Publication Date

2006

Volume

51

Issue

5

Start / End Page

839 / 843

Location

Russia (Federation)

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Presenilin-1
  • Neurons
  • Mice
  • Jurkat Cells
  • Hyaluronan Receptors
  • Humans
  • Cells, Cultured
  • Cell Polarity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shvartsman, A. L., Sarantseva, S. V., Tatishcheva, I. A., Runova, O. L., Talalaeva, E. I., & Vitek, M. P. (2006). [Expression of presenilin 1 on the cell surface in motile polarized cells]. Biofizika, 51(5), 839–843.
Shvartsman, A. L., S. V. Sarantseva, Iu A. Tatishcheva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “[Expression of presenilin 1 on the cell surface in motile polarized cells].Biofizika 51, no. 5 (2006): 839–43.
Shvartsman AL, Sarantseva SV, Tatishcheva IA, Runova OL, Talalaeva EI, Vitek MP. [Expression of presenilin 1 on the cell surface in motile polarized cells]. Biofizika. 2006;51(5):839–43.
Shvartsman, A. L., et al. “[Expression of presenilin 1 on the cell surface in motile polarized cells].Biofizika, vol. 51, no. 5, 2006, pp. 839–43.
Shvartsman AL, Sarantseva SV, Tatishcheva IA, Runova OL, Talalaeva EI, Vitek MP. [Expression of presenilin 1 on the cell surface in motile polarized cells]. Biofizika. 2006;51(5):839–843.

Published In

Biofizika

ISSN

0006-3029

Publication Date

2006

Volume

51

Issue

5

Start / End Page

839 / 843

Location

Russia (Federation)

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Presenilin-1
  • Neurons
  • Mice
  • Jurkat Cells
  • Hyaluronan Receptors
  • Humans
  • Cells, Cultured
  • Cell Polarity